Simethicone
Drug Info:
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Simethicone
Brand names: Alka-Seltzer® Gas Relief, Colic® , Colicon®, Degas®, Equalizer® Gas Relief Drops, Flatulex® Drops, Gas Relief, Gas Relief Dye-Free Infants, Gas Relief Extra Strength Softgel, Gas Relief Infants, Gas Relief Ultra, Gas-X® , Gas-X® Extra Strength, Gas-X® Infant , Gas-X® Maximum Strength , Genasyme®, Infant Gas Relief Drops, Infantaire™ Gas, Little Tummys® Gas Relief, Maalox® Anti-Gas, Maalox® Anti-Gas Extra Strength, Maximum Strength GasAid®, Micon® 80, Mylanta® Gas, Mylaval®, Mylicon, Mylicon®, Mytab® Gas, Phazyme® Maximum Strength, Phazyme® Quick Dissolve, Phazyme® Ultra
- Drug Forms:
- Simethicone oral drops (below)
- Simethicone oral suspension (SonoRx®)
- Simethicone Chewable tablet
- Simethicone Oral capsule
- Simethicone Oral capsule, liquid filled
- Simethicone Oral dissolving film
- Simethicone Oral drops, suspension
- Simethicone Oral tablet
- Espa�ol:
- Gotas orales de simeticona
- Supensión oral de simeticona (SonoRx®)
- Simeticona, Tableta masticable
- Simeticona, Cápsula oral
- Simeticona, Cápsula oral
- Simeticona, Película que se disuelva por vía oral
- Simeticona Gotas orales, suspensión
- Simeticona, Tableta oral
Simethicone oral drops
What are simethicone oral drops?
SIMETHICONE (Mylicon® Infant Drops, Genasyme® Drops, Flatulex® Drops, and others) is an antiflatulent used to treat too much gas in the stomach and intestines. Swallowing too much air or eating foods that disagree often causes gas. Generic simethicone oral drops are available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• an unusual or allergic reaction to simethicone, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I take this medicine?
Take simethicone oral drops by mouth. Use the special dropper included with the medicine. For infants, the dosage can be mixed with one ounce of cool water, infant formula or other suitable liquids to ease administration. Follow the directions on the label. If your health care providers have given you special instructions, follow their directions instead of what is on the label. Do not take your medicine more often than directed.
Contact your pediatrician or health care professional regarding the use of this medicine in children. These drops are regularly recommended for use in children and infants.
What if I miss a dose?
If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What drug(s) may interact with simethicone?
• none reported
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking simethicone?
In general, simethicone is a very safe drug. Tell your health care prescriber if your symptoms get worse, or if you have severe pain, diarrhea, constipation, or blood in your stool.
What side effects may I notice from taking simethicone?
There are no reported side effects with simethicone.
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
American Heritage Stedman's Medical Dictionary:
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si·meth·i·cone
(sĭ-mĕth'ĭ-kōn')
n.
n.
A mixture of dimethyl polysiloxanes and silica gel that is used as an antiflatulent.
Saunders Veterinary Dictionary:
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simethicone
An antiflatulent substance consisting of a mixture of dimethyl polysiloxanes and silica gel. Called also activated dimethicone.
Wikipedia on Answers.com:
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Simethicone
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| Systematic (IUPAC) name | |
| Poly(dimethylsiloxane), silicon dioxide | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | ? |
| Legal status | OTC (US) |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | not absorbed from the gut |
| Protein binding | N/A |
| Metabolism | N/A |
| Half-life | N/A |
| Excretion | N/A |
| Identifiers | |
| CAS number | 8050-81-5  |
| ATC code | A03AX13 |
| PubChem | CID 6433516 |
| ChEMBL | CHEMBL1200838  |
| Chemical data | |
| Formula | (C2H6OSi)n · (SiO2)m |
| Mol. mass | variable |
 (what is this?) (verify) |
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Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. It is a mixture of polydimethylsiloxane and hydrated silica gel.
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Contents
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Chemical action and pharmaceutical effects
Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the stomach that can be passed more easily. Simethicone does not reduce or prevent the formation of gas in the digestive tract, rather, it increases the rate at which it exits the body.[1] However, simethicone can relieve pain caused by gas in the intestines by decreasing foaming which then allows for passing of flatus. Simethicone is not absorbed by the body into the bloodstream, and is therefore considered relatively safe. National Institutes of Health (NIH)[2] reports there are usually no side effects when Simethicone is taken as directed. Although simethicone has also been promoted as a treatment for colic, randomised controlled trials have not demonstrated efficacy for such use.[3][4]
Simethicone solutions of differing concentration also have industrial applications for reducing foaming in certain chemical processes.
The use of simethicone can help reduce visual obstructions caused by intestinal gas during ultrasounds of the abdomen, although it has no effect on extraluminal gas outside the colon.
Dosage
Simethicone comes in many different oral forms, which have differing usual dosages. Though there are standard dosages for adults and teens, dosages for children should be determined by a doctor.
- Capsules or tablets:
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- Adults and teenagers: 60 to 125 milligrams (mg) four times a day, or 180mg twice a day, after meals and at bedtime. No more than 500 mg should be taken in twenty-four hours.
- Chewable tablets:
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- Adults and teenagers: 40 to 125 mg four times a day, after meals and at bedtime or the dose may be 150 mg three times a day, after meals. No more than 500 mg should be taken in twenty-four hours.
- Suspension:
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- Adults and teenagers: 40 to 95 mg four times a day, after meals and at bedtime. No more than 500 mg should be taken in twenty-four hours.
- Dissolving membrane:
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- A thin dissolving membrane dose that is placed on the tongue and dissolves with saliva. No more than 500 mg should be taken in twenty-four hours.
Availability
Simethicone is generally available over the counter under many brand names in varying dosage sizes and combinations with other drugs, including:
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- Rantac-MPS(UNIQUE PHARMA, India)
Other uses
Simethicone is used in some detergents when foaming is unwanted.
Simethicone is also used in the fermentation process to reduce the shearing of proteins by agitation.
Side effects
Simethicone has no known side effects.[7][8]
References
- ^ Norton, William (2005-01-09). "Controlling Intestinal Gas". http://www.iffgd.org/store/viewproduct/155. Retrieved 2007-07-31.
- ^ PubMed Health, produced by National Center for Biotechnology, a division of the National Library of Medicine at the National Institutes of Health; see http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000747/
- ^ University of Michigan clinical trial for simethicone used for colic
- ^ Patient.co.uk on colic
- ^ Product information (German)
- ^ Product information (German)
- ^ Simethicone Side Effects from Drugs.com. Retrieved Jan 2012
- ^ simethicone - oral from MedicineNet. Retrieved Jan 2012
External links
- "Jackson Gastroenterology - Patient Education - Simethicone". http://www.gicare.com/pated/simethicone.htm. Retrieved July 30, 2005.
- "Medline Plus - Simethicone". Archived from the original on February 19, 2007. http://web.archive.org/web/20070219022008/http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682683.html. Retrieved April 16, 2007.
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Copyrights:
American Heritage Stedman's Medical Dictionary
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company.
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Saunders Veterinary Dictionary
Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.
Read more
