Slit is a midline repellant molecule that prevents the crossing of longitudinal axons through the midline of the brain and spinal cord of a variety of animal species including mice and chickens.[1] It also prevents the recrossing of commissural axons. Its canonical receptor is Robo but it may have other receptors. This signaling molecule is secreted by the floor plate and diffuses outward. This Slit/Robo signaling is important in pioneer axon guidance. There are several versions of this gene and they are called Slit1 and Slit2 in the literature.
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