The Slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.
It induced prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2]
References
- ^ "Dorland's Medical Dictionary". http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_s_27zPzhtm. Retrieved December 15, 2006.
- ^ Howard R. Morris, Graham W. Taylor, Priscilla J. Piper, John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". http://www.nature.com/nature/journal/v285/n5760/abs/285104a0.html. Retrieved December 15, 2006.
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