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Small cell carcinoma

 
WordNet: small cell carcinoma
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The noun has one meaning:

Meaning #1: highly malignant carcinoma composed of small round or egg-shaped cells with little cytoplasm; lung cancers are frequently oat cell carcinomas
  Synonym: oat cell carcinoma

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Wikipedia: Small cell carcinoma
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Small cell carcinoma
Classification and external resources

Histopathologic image of small cell carcinoma of the lung. CT-guided core needle biopsy. H & E stain.
ICD-O: M8041/3
MedlinePlus 000122
eMedicine med/1336
MeSH D018288

Small cell carcinoma is a type of highly malignant[1] carcinoma usually associated with the lung, though it can be associated with other topographies, such as in cervical cancer.

Contents

Types

Paraneoplastic Syndromes: Small cell carcinomas produce ACTH and ADH, which can lead to SIADH.

Lung

When associated with the lung, it is sometimes called "oat cell carcinoma" due to the flat cell shape and scanty cytoplasm.

It is thought to originate from neuroendocrine cells (APUD cells) in the bronchus called Feyrter cells (named for Friedrich Feyrter),[2] and often leads to ectopic production of hormones ADH and ACTH.

It is more metastatic than non-small cell lung carcinoma[3] (and hence staged differently) and is sometimes seen in combination with squamous cell carcinomas.

Smoking is a significant etiological factor.

Symptoms and signs are as for other lung cancers. In addition, because of their neuroendocrine cell origin, small cell carcinomas will often secrete substances that result in paraneoplastic syndromes such as Lambert-Eaton myasthenic syndrome.

Prostate

In the prostate, small cell carcinoma is a rare form of cancer.[4] Due to the fact that there is little variation in prostate specific antigen levels, this form of cancer is normally diagnosed at an advanced stage.

It can metastasize to the brain.[5]

See also

References

  1. ^ small cell carcinoma at Dorland's Medical Dictionary
  2. ^ Champaneria MC, Modlin IM, Kidd M, Eick GN (2006). "Friedrich Feyrter: a precise intellect in a diffuse system". Neuroendocrinology 83 (5-6): 394–404. doi:10.1159/000096050. PMID 17028417. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000096050. 
  3. ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 759. ISBN 0-7216-0187-1. 
  4. ^ Nutting C, Horwich A, Fisher C, Parsons C, Dearnaley DP (June 1997). "Small-cell carcinoma of the prostate". Journal of the Royal Society of Medicine 90 (6): 340–1. PMID 9227387. 
  5. ^ Erasmus CE, Verhagen WI, Wauters CA, van Lindert EJ (November 2002). "Brain metastasis from prostate small cell carcinoma: not to be neglected". Can J Neurol Sci 29 (4): 375–7. PMID 12463494. http://cjns.metapress.com/openurl.asp?genre=article&issn=0317-1671&volume=29&issue=4&spage=375. 

Additional images

Anaplastic (microcellular, oat cell) carcinoma from the lung (histopathology)

Histopathologic image of small cell carcinoma of the lung. CT-guided core needle biopsy.

External links

v • d • e
Glandular and epithelial neoplasms (ICD-O 8010-8589)
Epithelium
Papilloma/carcinoma
(8010-8139)
Glands
Other/multiple
Cystic general
Acinar cell (8550-8559)
Other
Complex epithelial (8560-8589)
v • d • e
Tumors: Mediastinal tumors/Thoracic neoplasm/respiratory neoplasia (C30-C34/D14, 160-163/212.0-212.4)
Upper RT
Lower RT: lung
Small cell carcinoma
no major subgroups
Other than carcinoma
By location
Pleura
respiratory system navs: anat nose,larynx/lower+thoracic cavity/physio/dev, noncongen/congen/tumors, symptoms+signs/eponymous, proc
v • d • e
Tumors: urogenital neoplasia · genital neoplasia (C51-C63/D25-29, 179-187/218-222)
Female
Male
reproductive system navs: anat female,male/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc
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Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Small cell carcinoma".  Read more