Sophia Charlotte or Sophie Charlotte may refer to:
- Charlotte of Mecklenburg-Strelitz (1744 – 1818), Queen of the United Kingdom as spouse of George III
- Sophia Charlotte of Hanover (1668 – 1705), daughter of Ernst August, Elector of Hanover
- Charlotte Sophie, Duchess of Saxe-Coburg-Saalfeld (1731 — 1810), German duchess
- Duchess Sophie Charlotte in Bavaria (1847–1897), Duchess of Alençon and born Duchess in Bavaria
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