Sophie's Choice can refer to:
- Sophie's Choice (novel), a 1979 novel written by William Styron
- "Sophie's choice", a forced decision in which any and all options have equally negative outcomes, an idiom derived from the novel
- Sophie's Choice (film), a 1982 film based on Styron's novel
- Sophie's Choice (opera), a 2002 opera by Nicholas Maw based on Styron's novel
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