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| Systematic (IUPAC) name | |
|---|---|
| (1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one | |
| Identifiers | |
| CAS number | 1695-77-8 |
| ATC code | J01XX04 |
| PubChem | 15541 |
| DrugBank | APRD01232 |
| Chemical data | |
| Formula | C14H24N2O7 |
| Mol. mass | 332.35 g/mol |
| Synonyms | (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status |
not available in US |
| Routes | ? |
Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol antibiotic, closely related to the aminoglycosides, produced by the bacterium Streptomyces spectabilis.
There was a disruption in the supply in 2001.[1]
Contents |
Mechanism
It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis.
One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida.[2]
Uses
It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. This antibiotic is no longer available in the United States
Side effects
Side effects include itching, chills, stomach-ache, and red rash.
References
- ^ "From the Centers for Disease Control and Prevention. Update on spectinomycin availability in the United States". JAMA 286 (11): 1308–9. September 2001. PMID 11575327. http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=11575327.
- ^ Kehrenberg C, Schwarz S (June 2007). "Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida". Antimicrob. Agents Chemother. 51 (6): 2244–6. doi:. PMID 17371823.
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