spermidine

Spermidine
IUPAC name	N-(3-aminopropyl)butane-1,4-diamine
Other names	1,5,10-triazadecane
Identifiers
CAS number	124-20-9 Y
PubChem	1102
MeSH	Spermidine
SMILES	C(CCNCCCN)CN
Properties
Molecular formula	C7H19N3
Molar mass	145.246
Density	0.925 g/mL at 25 °C
Melting point	22-25.0 °C
Y (what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Spermidine is a polyamine involved in cellular metabolism that can be used to stimulate the enzyme, T7 RNA polymerase, a type of RNA polymerase. Spermidine has also been found to reduce the amount of ageing in yeast, flies, worms and human immune cells by inducing autophagy^[1].

Biochemical actions

• Inhibits neuronal nitric oxide synthase (nNOS).
• Binds and precipitates DNA.
• May be used for purification of DNA binding proteins.
• Stimulates T4 polynucleotide kinase activity.

Some of the uses

• Can be used in electroporation while transferring the DNA into the cell under the electrical impulse.

See also

• Norspermidine
• Spermine
• Putrescine

References

1. ^ Eisenberg et al. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology

External links

• Safety Data Sheet