St Columb may refer to:
People
- Columba, also known as St Columb of Scotland
- Saint Columba the Virgin, also known as St Columb of Cornwall
Places
In Northern Ireland
- St Columb's Cathedral, Derry
- St Columb's College, Derry
In Cornwall, UK
In fiction
- Lady Dona St Columb, character in Frenchman's Creek by Daphne du Maurier
- The Monastery of St Columb, book by Regina Maria Roche
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