| edit |
| Signal transducer and activator of transcription 6, interleukin-4 induced | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C | ||||||||||
| External IDs | OMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6 Gene | ||||||||||
|
|||||||||||
| RNA expression pattern | |||||||||||
 |
|||||||||||
 |
|||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 6778 | 20852 | |||||||||
| Ensembl | ENSG00000166888 | ENSMUSG00000002147 | |||||||||
| UniProt | P42226 | P70383 | |||||||||
| RefSeq (mRNA) | NM_003153 | NM_009284 | |||||||||
| RefSeq (protein) | NP_003144 | NP_033310 | |||||||||
| Location (UCSC) | Chr 12: 55.78 - 55.79 Mb |
Chr 10: 127.05 - 127.06 Mb |
|||||||||
| PubMed search | [1] | [2] | |||||||||
STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.[1][2]
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[3]
Contents |
Interactions
STAT6 has been shown to interact with EP300,[4] CREB binding protein,[5][4] NFKB1,[6] Nuclear receptor coactivator 1,[5][7] IRF4[8] and SND1.[9]
See also
References
- ^ Leek JP, Hamlin PJ, Bell SM, Lench NJ (1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3-4): 208–9. doi:. PMID 9605853.
- ^ Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor: IL-4 Stat". Science (journal) 265 (5179): 1701–6. doi:. PMID 8085155. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8085155.
- ^ "Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6778.
- ^ a b McDonald, C; Reich N C (Jul. 1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6". J. Interferon Cytokine Res. (UNITED STATES) 19 (7): 711–22. doi:. ISSN 1079-9907. PMID 10454341.
- ^ a b Litterst, C M; Pfitzner E (Dec. 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". J. Biol. Chem. (United States) 276 (49): 45713–21. doi:. ISSN 0021-9258. PMID 11574547.
- ^ Shen, C H; Stavnezer J (Jun. 1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3395–404. ISSN 0270-7306. PMID 9584180.
- ^ Litterst, Claudia M; Pfitzner Edith (Sep. 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". J. Biol. Chem. (United States) 277 (39): 36052–60. doi:. ISSN 0021-9258. PMID 12138096.
- ^ Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. ISSN 0022-1007. PMID 10601358.
- ^ Yang, Jie; Aittomäki Saara, Pesu Marko, Carter Kara, Saarinen Jussi, Kalkkinen Nisse, Kieff Elliott, Silvennoinen Olli (Sep. 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". EMBO J. (England) 21 (18): 4950–8. ISSN 0261-4189. PMID 12234934.
Further reading
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:. PMID 10856136.
- Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1–24. doi:. PMID 12039028.
- Hou J, Schindler U, Henzel WJ, et al. (1994). "An interleukin-4-induced transcription factor: IL-4 Stat.". Science 265 (5179): 1701–6. doi:. PMID 8085155.
- Takeda K, Tanaka T, Shi W, et al. (1996). "Essential role of Stat6 in IL-4 signalling.". Nature 380 (6575): 627–30. doi:. PMID 8602263.
- Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.". Nature 380 (6575): 630–3. doi:. PMID 8602264.
- Kotanides H, Reich NC (1996). "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene.". J. Biol. Chem. 271 (41): 25555–61. doi:. PMID 8810328.
- Mikita T, Campbell D, Wu P, et al. (1996). "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6.". Mol. Cell. Biol. 16 (10): 5811–20. PMID 8816495.
- Shen CH, Stavnezer J (1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription.". Mol. Cell. Biol. 18 (6): 3395–404. PMID 9584180.
- Leek JP, Hamlin PJ, Bell SM, Lench NJ (1998). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization.". Cytogenet. Cell Genet. 79 (3-4): 208–9. doi:. PMID 9605853.
- Mikita T, Kurama M, Schindler U (1998). "Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta.". J. Immunol. 161 (4): 1822–8. PMID 9712049.
- Patel BK, Keck CL, O'Leary RS, et al. (1998). "Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors.". Genomics 52 (2): 192–200. doi:. PMID 9782085.
- Zhu M, John S, Berg M, Leonard WJ (1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.". Cell 96 (1): 121–30. doi:. PMID 9989503.
- McDonald C, Reich NC (1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6.". J. Interferon Cytokine Res. 19 (7): 711–22. doi:. PMID 10454341.
- Harris MB, Chang CC, Berton MT, et al. (2000). "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching.". Mol. Cell. Biol. 19 (10): 7264–75. PMID 10490661.
- Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.". J. Immunol. 163 (7): 3834–41. PMID 10490982.
- Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.". J. Exp. Med. 190 (12): 1837–48. doi:. PMID 10601358.
- Daniel C, Salvekar A, Schindler U (2000). "A gain-of-function mutation in STAT6.". J. Biol. Chem. 275 (19): 14255–9. doi:. PMID 10747856.
- Arinobu Y, Sugimoto R, Akaiwa M, et al. (2000). "Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells.". Biochem. Biophys. Res. Commun. 277 (2): 317–24. doi:. PMID 11032724.
- Masuda A, Matsuguchi T, Yamaki K, et al. (2001). "Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression.". J. Biol. Chem. 276 (28): 26107–13. doi:. PMID 11369758.
External links
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
