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| Route 19 | |||||||||||||
| Maintained by MoDOT | |||||||||||||
| Length: | 256 mi (412 km) | ||||||||||||
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| Formed: | 1922 | ||||||||||||
| North end: |  US 61 (Avenue of the Saints) in New London |
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| Major junctions: |
 US 54 in Laddonia Route 161 in Montgomery City  I-70/US 40 in New Florence Route 100 in Hermann US 50 North of Owensville I-44 in Cuba Route 8 in Steelville   Routes 32, 68 & 72 in Salem US 60 in Winona US 160 in Alton |
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| South end: |  US 63 in Thayer |
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| Major cities: | New London Center Laddonia Martinsburg Wellsville Montgomery City New Florence Big Spring McKittrick Hermann Owensville Cuba Steelville Cherryville Salem Gladden Eminence Winona Greer Alton Thayer |
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Route 19 is a long highway in Missouri. Its northern terminus is at U.S. Route 61 in New London; its southern terminus is at U.S. Route 63 on the north side of Thayer. Route 19 is one of Missouri's original 1922 highways, though it initially had a northern terminus at Route 14 (now Interstate 44) in Cuba and was later extended north.
Route 19 crosses the Missouri River at Hermann, a town famous in Missouri for its wineries, and crosses Historic U.S. Route 66 at Cuba. South of Cuba, it is a state scenic highway and passes by Indian Trail State Park northeast of Salem, crosses through the Ozark National Scenic Riverways twice, and passes through a part of the Mark Twain National Forest.
History
The part from Drake north to US 54 east of Mexico was Route 45 from 1922 until about 1930.
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