SSB might be an acronym or abbreviation for:
- The Super Smash Bros. series.
- Super Smash Bros., the first game in the Super Smash Bros. series.
- Salomon Smith Barney, a former investment firm, now part of CitiGroup
- Sathya Sai Baba
- Schulich School of Business, a business school in York University
- Services Selection Board – Selection board for selecting cadets to be trained to become Indian Army officers.
- SG-SSB, or “Societe Generale – Social Security Bank”, in Ghana.
- Ship Submersible Ballistic, the US Navy name for a ballistic missile submarine
- Single-sideband modulation in radio technology
- Single-strand binding protein
- Single-stranded DNA Break
- Societas Sanctae Birgittae, the Society of Saint Bridget
- Spontaneous symmetry breaking, a concept in Physics
- Star Spangled Banner, the national anthem of the United States
- State Street Bank, a financial services provider. Offers benchmarking, investment management and securities administration.
- Statistisk Sentralbyrå, the Norwegian statistics bureau
- Strategic Support Branch
- Stuttgarter Straßenbahnen AG, public transport operator in Stuttgart, Germany
- Sunshine Skyway Bridge
- Sustainable South Bronx, environmental justice organization
- SouthSide Boys, an all-male a cappella group from SUNY Geneseo
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