| Sulfhemoglobinemia | |
|---|---|
| Classification and external resources | |
| ICD-10 | D74.8 |
| ICD-9 | 289.7 |
| MedlinePlus | 003371 |
| MeSH | D013436 |
Sulfhemoglobinemia (or sulfhemoglobinaemia) is a rare condition in which there is excess sulfhemoglobin (SulfHb) in the blood. The pigment is a greenish derivative of hemoglobin which cannot be converted back to normal, functional hemoglobin. It causes cyanosis even at low blood levels.
It is a rare blood condition that occurs when a sulfur atom is incorporated into the hemoglobin molecule. When hydrogen sulfide (H2S) (or sulfide ions) and ferric ions combine in the blood, the blood is incapable of carrying oxygen.
Contents |
Causes
This can be caused by taking medications that contain sulfonamides under certain conditions (i.e. overdosing of sumatriptan).
Sulfhemoglobinemia is usually drug induced. Drugs associated with sulfhemoglobinemia include acetanilid, phenacetin, nitrates, trinitrotoluene and sulfur compounds (mainly sulphonamides). Another possible cause is occupational exposure to sulfur compounds.
It can be caused by phenazopyridine.[1]
Prognosis and treatment
The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be necessary in extreme cases.
Presentation
Symptoms include a blueish or greenish discoloration of the blood, skin, and mucous membranes, even though a blood count test may not show any abnormalities in the blood.
Notable cases
On June 11, 2007, Canadian anesthesiologists Dr. Stephan Schwarz, Dr. Giuseppe Del Vicario, and Dr. Alana Flexman presented an unusual case in The Lancet.[2] A 42-year-old male patient was brought into Vancouver's St. Paul's Hospital after falling asleep in a sitting position. When doctors drew the man's blood during surgery to relieve pressure from his legs, the blood was green. A sample of the blood was immediately sent to a lab. In this case, sulfhemoglobinaemia was possibly caused by the patient taking higher-than-prescribed doses of sumatriptan.[3][4][5]
References
- ^ Gopalachar AS, Bowie VL, Bharadwaj P (June 2005). "Phenazopyridine-induced sulfhemoglobinemia". Ann Pharmacother 39 (6): 1128–30. doi:. PMID 15886294. http://www.theannals.com/cgi/pmidlookup?view=long&pmid=15886294.
- ^ Flexman AM, Del Vicario G, Schwarz SK (June 2007). "Dark green blood in the operating theatre". Lancet 369 (9577): 1972. doi:. PMID 17560450. http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(07)60918-0.
- ^ "Patient bleeds dark green blood", BBC News, 8 June 2007
- ^ Also on FOX 11 June 2007
- ^ "Dark Green Blood In The Operating Theatre", Medical News Today, June 8, 2007
External links
 |
This disease article is a stub. You can help Wikipedia by expanding it. |
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
