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Sulfonamides may interact with a large number of other medicines. When this happens, the effects of one or both of the drugs may change or the risk of side effects may be greater. Anyone who takes sulfonamides should let the physician know all other medicines he or she is taking. Among the drugs that may interact with sulfonamides are:
- acetaminophen (Tylenol)
- medicine for overactive thyroid
- male hormones (androgens)
- female hormones (estrogens)
- other medicines used to treat infections
- birth control pills
- medicines for diabetes such as glyburide (Micronase)
- anticoagulants such as warfarin (Coumadin)
- disulfiram (Antabuse), used to treat alcohol abuse
- amantadine (Symmetrel), used to treat flu and also Parkinson's disease
- water pills (diuretics) such as hydrochlorothiazide (HCTZ, Hydro DIURIL)
- the anticancer drug methotrexate (Rheumatrex)
- antiseizure medicines such as valproice acid (Depakote, Depakene)
The list above does not include every drug that may interact with sulfonamides. Be sure to check with a physician or pharmacist before combining sulfonamides with any other prescription or nonprescription (over-thecounter) medicine.
[Article by: Nancy Ross-Flanigan]
— Nancy Ross-Flanigan
