Sulprostone

Sulprostone
Systematic (IUPAC) name
(Z)-7-[(1R,3R)-3-Hydroxy-2-[(E,3R)-3-hydroxy-4- (phenoxy)but-1-enyl]-5-oxocyclopentyl]-N-methylsulfonylhept-5-enamide
Identifiers
CAS number	60325-46-4
ATC code	G02AD05
PubChem	6917982
Chemical data
Formula	C23H31NO7S
Mol. mass	465.56 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Sulprostone is an oxytocic.

It is an analogue of prostaglandin E2.^[1]

References

1. ^ Tamma G, Wiesner B, Furkert J, et al. (August 2003). "The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho". Journal of cell science 116 (Pt 16): 3285–94. doi:10.1242/jcs.00640. PMID 12829746. http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=12829746. 

v • d • e Oxytocics (G02A) Ergot alkaloids Methylergometrine · Ergot alkaloids · Ergometrine# Prostaglandins (E/F) Dinoprost · Dinoprostone · Prostaglandin analogues (Gemeprost, Carboprost, Sulprostone, Misoprostol#) Other Oxytocin# #WHO-EM. †Undergoing clinical trials, not FDA approved. ‡Withdrawn from market. §Development halted.

v • d • e Autacoids, unsaturated fatty acids: Eicosanoids Precursor Arachidonic acid Prostanoids Prostaglandins (PG) and analogues Precursor H2 Active D/J D2 E/F E2 (Dinoprostone): Enprostil · Sulprostone E1 (Alprostadil): Misoprostol · Gemeprost F2α (Dinoprost): Bimatoprost · Carboprost · Latanoprost · Tafluprost · Travoprost · Unoprostone I I2 (Prostacyclin/Epoprostenol): Beraprost · Iloprost · Treprostinil Thromboxanes (TX) A2 · B2 Leukotrienes (LT) Precursor Arachidonic acid 5-hydroperoxide Initial A4 · B4 SRS-A C4 · D4 · E4 Nonclassic Lipoxins (A4, B4) · Virodhamine By function bronchoconstriction (PGF2α, TXA2, LTC4, LTD4, LTE4) vasoconstriction (PGF2α, TXA2, TXB2) · vasodilation (PGE2, PGI2, LTC4, LTD4, LTE4) platelets: induce (TXA2) inhibit (PGD2, PGI2) · leukocytes: induce (TXA2, LTB4) inhibit (PGD2, PGE2) labor stimulation: (PGE2 (Dinoprostone), PGF2α (Dinoprost)) see also enzymes

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