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Syntrophin, alpha 1

 
Wikipedia: Syntrophin, alpha 1
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Syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
PBB Protein SNTA1 image.jpg
PDB rendering based on 1qav.
Available structures
1qav, 1z86, 1z87, 2pdz
Identifiers
Symbols SNTA1; SNT1; TACIP1; dJ1187J4.5
External IDs OMIM: 601017 MGI: 101772 HomoloGene: 2331
RNA expression pattern
PBB GE SNTA1 203516 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6640 20648
Ensembl ENSG00000101400 ENSMUSG00000027488
UniProt Q13424 Q3UVD6
RefSeq NM_003098 (mRNA) NM_009228 (mRNA)
NP_003089 (protein) NP_033254 (protein)
Location Chr 20:
31.46 - 31.5 Mb		 Chr 2:
154.07 - 154.1 Mb
PubMed search [1] [2]

Alpha-1-syntrophin is a protein that in humans is encoded by the SNTA1 gene.[1][2][3]

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.[3]

Interactions

Syntrophin, alpha 1 has been shown to interact with Dystrophin,[1][4][5] Nav1.1[5] and Nav1.5.[5]

References

  1. ^ a b Ahn AH, Freener CA, Gussoni E, Yoshida M, Ozawa E, Kunkel LM (Mar 1996). "The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives". J Biol Chem 271 (5): 2724-30. PMID 8576247. 
  2. ^ Castello A, Brocheriou V, Chafey P, Kahn A, Gilgenkrantz H (Jun 1996). "Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast". FEBS Lett 383 (1-2): 124-8. PMID 8612778. 
  3. ^ a b "Entrez Gene: SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6640. 
  4. ^ Yang, B; Jung D, Rafael J A, Chamberlain J S, Campbell K P (Mar. 1995). "Identification of alpha-syntrophin binding to syntrophin triplet, dystrophin, and utrophin". J. Biol. Chem. (UNITED STATES) 270 (10): 4975-8. ISSN 0021-9258. PMID 7890602. 
  5. ^ a b c Gee, S H; Madhavan R, Levinson S R, Caldwell J H, Sealock R, Froehner S C (Jan. 1998). "Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins". J. Neurosci. (UNITED STATES) 18 (1): 128-37. ISSN 0270-6474. PMID 9412493. 

Further reading

  • Miyagoe-Suzuki Y, Takeda SI (2002). "Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma.". Microsc. Res. Tech. 55 (3): 164–70. doi:10.1002/jemt.1167. PMID 11747091. 
  • Blake DJ (2002). "Dystrobrevin dynamics in muscle-cell signalling: a possible target for therapeutic intervention in Duchenne muscular dystrophy?". Neuromuscul. Disord. 12 Suppl 1: S110–7. PMID 12206805. 
  • Yang B, Jung D, Rafael JA, et al. (1995). "Identification of alpha-syntrophin binding to syntrophin triplet, dystrophin, and utrophin.". J. Biol. Chem. 270 (10): 4975–8. PMID 7890602. 
  • Gee SH, Madhavan R, Levinson SR, et al. (1998). "Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.". J. Neurosci. 18 (1): 128–37. PMID 9412493. 
  • Iwata Y, Pan Y, Yoshida T, et al. (1998). "Alpha1-syntrophin has distinct binding sites for actin and calmodulin.". FEBS Lett. 423 (2): 173–7. PMID 9512352. 
  • Hasegawa M, Cuenda A, Spillantini MG, et al. (1999). "Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.". J. Biol. Chem. 274 (18): 12626–31. PMID 10212242. 
  • Hillier BJ, Christopherson KS, Prehoda KE, et al. (1999). "Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.". Science 284 (5415): 812–5. PMID 10221915. 
  • Fernández-Larrea J, Merlos-Suárez A, Ureña JM, et al. (1999). "A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.". Mol. Cell 3 (4): 423–33. PMID 10230395. 
  • Lumeng C, Phelps S, Crawford GE, et al. (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.". Nat. Neurosci. 2 (7): 611–7. doi:10.1038/10165. PMID 10404183. 
  • Adams ME, Kramarcy N, Krall SP, et al. (2000). "Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.". J. Cell Biol. 150 (6): 1385–98. PMID 10995443. 
  • Newey SE, Benson MA, Ponting CP, et al. (2001). "Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex.". Curr. Biol. 10 (20): 1295–8. PMID 11069112. 
  • Olalla L, Aledo JC, Bannenberg G, Márquez J (2001). "The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.". FEBS Lett. 488 (3): 116–22. PMID 11163757. 
  • Marchand S, Stetzkowski-Marden F, Cartaud J (2001). "Differential targeting of components of the dystrophin complex to the postsynaptic membrane.". Eur. J. Neurosci. 13 (2): 221–9. PMID 11168526. 
  • Xu H, Goldfarb M (2001). "Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells.". J. Biol. Chem. 276 (16): 13049–56. doi:10.1074/jbc.M009925200. PMID 11278583. 
  • Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924. 
  • Oak SA, Russo K, Petrucci TC, Jarrett HW (2001). "Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.". Biochemistry 40 (37): 11270–8. PMID 11551227. 
  • Adams ME, Mueller HA, Froehner SC (2001). "In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4.". J. Cell Biol. 155 (1): 113–22. doi:10.1083/jcb.200106158. PMID 11571312. 
  • Neely JD, Amiry-Moghaddam M, Ottersen OP, et al. (2002). "Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein.". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 14108–13. doi:10.1073/pnas.241508198. PMID 11717465. 
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