TFC is known to stand for the following:
- Teens For Christ, A Ministry in Lima Ohio
- Terrace F. Club, an eating club at Princeton university
- Tanglewood Festival Chorus, the Boston Symphony's chorus since 1970
- Team Fortress Classic, a first-person shooter video game
- Teenage Fanclub
- The Filipino Channel
- The Final Cut
- Thin film composite membrane
- Tactical Fusion Cube, a type of Borg cube from Star Trek: Armada II which is known as the strongest starship in the game, capable of destroying entire bases alone
- Trooper First Class, a rank in some state police organizations
- Turner Fenton Campus, a high school in Brampton, Ontario, Canada (now renamed to Turner Fenton Secondary School)
- Total Fight Challenge, an American mixed martial arts organization
- Team Feasibility Commitment, a term used in automotive industry
- Traffic Flow Confidentiality, a form of telecommunication security.
It may also refer to one of the following football clubs:
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