TC-5619: Information from Answers.com


TC-5619
Systematic (IUPAC) name
N-[(2S,3S)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2-carboxamide
Identifiers
CAS number	?
ATC code	?
PubChem	16727410
Chemical data
Formula	C₂₂H₂₃N₃O₂
Mol. mass	361.437
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

TC-5619 is a drug developed by Targacept which acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and is currently being developed through a collaboration between Targacept and AstraZeneca as a potential treatment for schizophrenia.^[1] Phase I clinical trials have been completed successfully and it is currently in Phase II trials.^[2]

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References

Stimulants

Anti-Adenosinergics

Xanthines	Bamifylline • Caffeine • CPX‎ • Dimethazan • DPCPX • DPPX • Fenethylline • Istradefylline • Paraxanthine • Rolofylline • Theobromine • Theophylline

Others	Preladenant • SCH-58,261 • SCH-412,348 • SCH-442,416 • ZM-241,385

Convulsants
Anti-GABAergics

Bicuculline • DMCM • Flumazenil • Flurothyl • Gabazine • Oenanthotoxin • Pentetrazol • Picrotoxin • Ro15-4513 • Sarmazenil • Strychnine • Thujone

Parasympathomimetics
Cholinergics

ABT-089 • ABT-418 • Acetylcarnitine • Alpha-GPC • Anabasine • Arecoline • Choline • Cotinine • Cytisine • Dianicline • Dimethylphenylpiperazinium • DMAE • Epibatidine • Epiboxidine • GTS-21 • Ispronicline • Muscarine • Nicotine • Rivanicline • TC-5619 • Tebanicline • Varenicline

Sympathomimetics
Catecholaminergics

Adamantanes	Adaphenoxate • Adapromine • Amantadine • Bromantane • Chlodantane • Gludantane • Memantine • Midantane

Arylcyclohexylamines	Benocyclidine • Dieticyclidine • Esketamine • Eticyclidine • Gacyclidine • Ketamine • Phencyclamine • Phencyclidine • Rolicyclidine • Tenocyclidine • Tiletamine

Benzazepines	6-Br-APB • SKF-38,393 • SKF-81,297 • SKF-82,958 • SKF-83,959

Oxazolines	4-Methylaminorex • Aminorex • Clominorex • Cyclazodone • Fenozolone • Fluminorex • Pemoline • Thozalinone

Phenylalkylamines	1-Phenyl-2-methylaminobutan-1-one • 2-Fluoroamphetamine • 2-OH-PEA • 2-Phenyl-3-aminobutane • 2-Phenyl-3-methylaminobutane • 4-Ethylamphetamine • 4-FA • 4-FMA • 4-MA • 4-MMA • 4-MTA • Alfetamine • α-Ethylphenethylamine • Amfepentorex • Amidephrine • Amphechloral • Amphetamine (Dextroamphetamine, Levoamphetamine) • Amphetaminil • Arbutamine • Atomoxetine (Tomoxetine) • β-Methylphenethylamine • Benfluorex • Benzphetamine • BPAP • Brephedrone • Bupropion • Butylone • Cathine • Cathinone • Chlephedrone • Chlorphentermine • Clenbuterol • Clobenzorex • Clortermine • Denopamine • Desvenlafaxine • Dibutylone • Diethylcathinone • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone • Dobutamine • DOPA (Dextrodopa, Levodopa) • Dopamine • Dopexamine • Droxidopa • Duloxetine • Ephedrine • Epinephrine (Adrenaline) • Epinine • Etafedrine • Ethcathinone • Ethylamphetamine • Ethylone • Etilefrine • Fenbutrazate • Fencamine • Fencamfamine • Fenethylline • Fenproporex • Flephedrone • Fludorex • Furfenorex • Gepefrine • HMA • HMMA • Hordenine • Ibopamine • Indanorex • Iodephedrone • Isoetarine • Isoprenaline • Lefetamine • Lisdexamfetamine • Manifaxine • MBDB • MDA • MDEA • MDMA • MDOH • Medifoxamine • Mefenorex • Mephedrone • Mephentermine • Metanephrine • Metaraminol • Methamphetamine (Dextromethamphetamine, Levomethamphetamine) • Methoxamine • Methoxyphenamine • MMA • Methcathinone • Methedrone • Methoxyphenamine • Methylone • MMDA • Nisoxetine • Norepinephrine (Noradrenaline) • Norfenefrine • Normetanephrine • Octopamine • Orciprenaline • Ortetamine • Oxaflozane • Oxilofrine • Paredrine (Norpholedrine) • PBA • PCA • PHA • Phendimetrazine • Phenmetrazine • Phenpentermine • Phenpromethamine • Phentermine • Phenylalanine • Phenylephrine (Neosynephrine) • Phenylpropanolamine • Pholedrine • PIA • PMA • PMEA • PMMA • PPAP • Propylamphetamine • Pseudoephedrine • Radafaxine • Reboxetine • Ropinirole • Salbutamol (Albuterol; Levosalbutamol) • Selegiline (L-Deprenyl) • Sibutramine • Synephrine (Oxedrine) • Theodrenaline • Tiflorex • Tranylcypromine • Tyramine • Tyrosine • Venlafaxine • Xamoterol • Xylopropamine • Zylofuramine

Piperazines	2C-B-BZP • BZP • DBL-583 • DBZP • GBR-12,783 • GBR-12,935 • GBR-13,069 • GBR-13,098 • GBR-13,119 • MBZP • MDBZP • MeOPP • Vanoxerine

Piperidines	2-Benzylpiperidine • 4-Benzylpiperidine • Desoxypipradrol • Diphemethoxidine • Ethylphenidate • HDMP-28 ((-)-HDMP-28) • Methylphenidate (Dexmethylphenidate) • Nocaine • Phacetoperane • Pipradrol

Pyrrolidines	α-PBP • α-PPP • α-PVP • MDPBP • MDPPP • MDPV • MOPPP • MPBP • MPHP • MPPP • Prolintane • Pyrovalerone

Quinolines	A-86929 • Dihydrexidine • Dinapsoline • Dinoxyline • Doxanthrine

Tropanes	3α-Bis-(4-fluorophenyl)methoxytropane • 3α-((4-Chlorophenyl)phenylmethoxy)tropane • 3-Pseudotropyl-4-fluorobenzoate • Altropane • Brasofensine • β-CFT (WIN 35,428) • β-CIT (RTI-55) • β-CPT (Troparil; WIN-35,065-2) • β-CPPIT • Cocaethylene • Cocaine • Dichloropane (RTI-111) • Difluoropine • FE-β-CPPIT • FP-β-CPPIT • Ioflupane (¹²³I) • Norcocaine • PIT • PTT • RTI-31 • RTI-32 • RTI-51 • RTI-112 • RTI-113 • RTI-121 • RTI-126 • RTI-150 • RTI-171 • RTI-177 • RTI-336 • RTI-371 • RTI-386 • Tesofensine • Tropoxane • WF-23 • WF-33 • WF-60

Others	2-Aminoindane • 2-Aminotetralin • Amfonelic Acid • Amineptine • Amisulpride • Atipamezole • Benzatropine • Benzydamine • BTS-74,398 • Butyltolylquinuclidine • Clofenciclan • Cyclopentamine • Cypenamine • Cyprodenate • Diclofensine • Diphenylprolinol • Dimethocaine • DOV-102,677 • DOV-21,947 • DOV-216,303 • Efaroxan • Etybenzatropine • Feprosidnine • Gilutensin • GYKI-52,895 • Heptaminol • Idazoxan • Indanylaminopropane • Indatraline • Isometheptene • Lazabemide • LR-5182 • Maprotiline • Mazindol • Mesocarb • Methylhexaneamine • Naphthylaminopropane • Nefopam • Nomifensine • NS-2359 • O-2172 • Octodrine • Oxaprotiline • Pargyline • Phthalimidopropiophenone • Propylhexedrine • Rasagiline • Rauwolscine • SEP-225,289 • SEP-227,162 • Sulpiride • Tametraline • Tandamine • Tapentadol • Thiophenylaminopropane • Tramadol • Tripelennamine • Tuaminoheptane • UH-232 • Yohimbine

Miscellaneous
Unsorted/Uncategorized

Eugeroics	Adrafinil • Armodafinil • Modafinil

Others	Carphedon • Hexacyclonate • Leptacline • Meclofexonate • Mefexamide

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