Tegafur

Tegafur

Systematic (IUPAC) name
5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Identifiers
CAS number	17902-23-7
ATC code	L01BC03
PubChem	5386
Chemical data
Formula	C8H9FN2O3
Mol. mass	200.16 g/mol
SMILES	eMolecules & PubChem
Synonyms	5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
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Tegafur (INN) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. When metabolized, it becomes 5-FU.

See also

• Tegafur-uracil

v • d • e Intracellular chemotherapeutic agents/antineoplastic agents (L01) SPs/MIs (M phase) Block microtubule assembly Vinca alkaloids (Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine) Block microtubule disassembly Taxanes (Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel) · Epothilones (Ixabepilone) DNA replication inhibitor DNA precursors/ antimetabolites (S phase) Folic acid dihydrofolate reductase inhibitor (Aminopterin, Methotrexate, Pemetrexed) · thymidylate synthase inhibitor (Raltitrexed, Pemetrexed) Purine adenosine deaminase inhibitor (Pentostatin) halogenated/ribonucleotide reductase inhibitors (Cladribine, Clofarabine, Fludarabine) thiopurine (Thioguanine, Mercaptopurine) Pyrimidine thymidylate synthase inhibitor (Fluorouracil, Capecitabine, Tegafur, Carmofur, Floxuridine) DNA polymerase inhibitor (Cytarabine) ribonucleotide reductase inhibitor (Gemcitabine) hypomethylating agent (Azacitidine, Decitabine) Deoxyribonucleotide ribonucleotide reductase inhibitor (Hydroxyurea) Topoisomerase inhibitors (S phase) I Camptotheca (Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan) II Podophyllum (Etoposide, Teniposide) II+Intercalation Anthracyclines (Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pirarubicin, Valrubicin, Zorubicin) · Anthracenediones (Mitoxantrone, Pixantrone) Crosslinking of DNA (CCNS) Alkylating Nitrogen mustards: Mechlorethamine · Cyclophosphamide (Ifosfamide, Trofosfamide) · Chlorambucil (Melphalan, Prednimustine) · Bendamustine · Uramustine · Estramustine Nitrosoureas: Carmustine · Lomustine (Semustine) · Fotemustine · Nimustine · Ranimustine · Streptozocin Alkyl sulfonates: Busulfan (Mannosulfan, Treosulfan) Aziridines: Carboquone · ThioTEPA · Triaziquone · Triethylenemelamine Alkylating-like Platinum (Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Nonclassical Hydrazines (Procarbazine) · Triazenes (Dacarbazine, Temozolomide) · Altretamine · Mitobronitol Intercalation Streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) Photosensitizers/PDT Aminolevulinic acid/Methyl aminolevulinate · Efaproxiral · Porphyrin derivatives (Porfimer sodium, Talaporfin, Temoporfin, Verteporfin) Other Enzyme inhibitors FI (Tipifarnib)  · CDK inhibitors (Alvocidib, Seliciclib) · PrI (Bortezomib) · PhI (Anagrelide) · IMPDI (Tiazofurine) · LI (Masoprocol) · PARP inhibitor (Olaparib) · HDAC (Vorinostat, Romidepsin) Receptor antagonists ERA (Atrasentan) · retinoid X receptor (Bexarotene) · sex steroid (Testolactone) Other/ungrouped Amsacrine · Trabectedin · retinoids (Alitretinoin, Tretinoin) · Arsenic trioxide · asparagine depleter (Asparaginase/Pegaspargase) · Celecoxib · Demecolcine · Elesclomol · Elsamitrucin · Etoglucid · Lonidamine · Lucanthone · Mitoguazone · Mitotane · Oblimersen · Temsirolimus

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