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Terlipressin
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| Systematic (IUPAC) name | |
| 1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-N-(2-amino-2-oxoethyl)-L-lysinamide | |
| Identifiers | |
| CAS number | 14636-12-5 |
| ATC code | H01BA04 |
| PubChem | 72081 |
| DrugBank | EXPT03310 |
| Chemical data | |
| Formula | C52H74N16O15S2 |
| Mol. mass | 1227.37 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | ~30% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | IV
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Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used in bleeding esophageal varices.[3]
Terlipressin is marketed under the brand names Haemopressin (IS Pharmaceuticals), Variquel (IS Pharmaceuticals) or Glypressin (Ferring Pharmaceuticals).
Availability
Terlipressin is currently not available in the United States,[4] or Canada.[5]
See also
References
- ^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. doi:. PMID 11955542.
- ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. doi:. PMID 10905585.
- ^ Ioannou G, Doust J, Rockey D (2003). "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. doi:. PMID 12535432.
- ^ "{1} And {2} Report Fast Track Designation For Terlipressin In Type 1 Hepatorenal Syndrome - News, Search Jobs, Events". http://www.biospace.com/news_story.aspx?NewsEntityId=19774820.
- ^ "Drug Product Search". http://205.193.93.51/dpdonline/searchRequest.do.
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