Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.
It is a tumor suppressor gene.[1]
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.[2]
Interactions
TGF beta receptor 2 has been shown to interact with Cyclin B2,[3] TGF beta receptor 1,[4][5] Transforming growth factor, beta 3,[6][7][8][9] AP2B1,[10] Endoglin,[11][8] Heat shock protein 90kDa alpha (cytosolic), member A1[12] and STRAP.[13][14]
See also
References
- ^ "TGFBR2 - transforming growth factor, beta receptor II (70/80kDa) - Genetics Home Reference". http://ghr.nlm.nih.gov/gene=tgfbr2. Retrieved on 2008-09-07.
- ^ "Entrez Gene: TGFBR2 transforming growth factor, beta receptor II (70/80kDa)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7048.
- ^ Liu, J H; Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y (Jan. 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene (ENGLAND) 18 (1): 269-75. doi:10.1038/sj.onc.1202263. ISSN 0950-9232. PMID 9926943.
- ^ Kawabata, M; Chytil A, Moses H L (Mar. 1995). "Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor". J. Biol. Chem. (UNITED STATES) 270 (10): 5625-30. ISSN 0021-9258. PMID 7890683.
- ^ Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. 2001). "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor". J. Biol. Chem. (United States) 276 (9): 6727-38. doi:10.1074/jbc.M008340200. ISSN 0021-9258. PMID 11102446.
- ^ De Crescenzo, Gregory; Pham Phuong L, Durocher Yves, O'Connor-McCourt Maureen D (May. 2003). "Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding". J. Mol. Biol. (England) 328 (5): 1173-83. ISSN 0022-2836. PMID 12729750.
- ^ Hart, P John; Deep Shashank, Taylor Alexander B, Shu Zhanyong, Hinck Cynthia S, Hinck Andrew P (Mar. 2002). "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex". Nat. Struct. Biol. (United States) 9 (3): 203-8. doi:10.1038/nsb766. ISSN 1072-8368. PMID 11850637.
- ^ a b Barbara, N P; Wrana J L, Letarte M (Jan. 1999). "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily". J. Biol. Chem. (UNITED STATES) 274 (2): 584-94. ISSN 0021-9258. PMID 9872992.
- ^ Rotzer, D; Roth M, Lutz M, Lindemann D, Sebald W, Knaus P (Feb. 2001). "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor". EMBO J. (England) 20 (3): 480-90. doi:10.1093/emboj/20.3.480. ISSN 0261-4189. PMID 11157754.
- ^ Yao, Diying; Ehrlich Marcelo, Henis Yoav I, Leof Edward B (Nov. 2002). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Mol. Biol. Cell (United States) 13 (11): 4001-12. doi:10.1091/mbc.02-07-0104. ISSN 1059-1524. PMID 12429842.
- ^ Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. 2002). "Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II". J. Biol. Chem. (United States) 277 (32): 29197-209. doi:10.1074/jbc.M111991200. ISSN 0021-9258. PMID 12015308.
- ^ Wrighton, Katharine H; Lin Xia, Feng Xin-Hua (Jul. 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (27): 9244-9. doi:10.1073/pnas.0800163105. PMID 18591668.
- ^ Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. (UNITED STATES) 273 (52): 34671-4. ISSN 0021-9258. PMID 9856985.
- ^ Datta, P K; Moses H L (May. 2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling". Mol. Cell. Biol. (UNITED STATES) 20 (9): 3157-67. ISSN 0270-7306. PMID 10757800.
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PDB Gallery |
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1ktz: Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3
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1m9z: CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN
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1plo: TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAIN
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Transmembrane receptors: immune receptors |
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Interleukins ( 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27)
CSF receptors (EPO, GM-CSF, G-CSF)
GH · prolactin · Oncostatin M · Leukemia inhibitory factor
common subunits ( Common gamma chain, common beta chain, gp130)
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