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Drugs with a low therapeutic index have a narrow margin of safety.

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Drugs with a low therapeutic index have a narrow margin of safety.

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The therapeutic index of drugs is the ratio between the amount of drug needed to kill 50% of the cells of the experimental animals and the dose needed for 50% of the cells to respond. The larger the therapeutic index, the safer the drug.

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It is for certain drugs such as Digoxin as they have such a narrow therapeutic index. For drugs with a wide range of therapeutic index, the best measure of safety is the maximum daily dose, its effect on the patient and what other drugs it interacts with. Ask your pharmacist for specific safety questions on your specific drugs.

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Digitalis has a very narrow therapeutic index, therefore, the dose must be carefully be monitored for each patient.

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