The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.
Metabolism is catalyzed by S-methyltransferase.[1]
See also
- 6-thioguanine (6-TG)
- 6-mercaptopurine (6-MP)
- Azathioprine (AZA)
References
- ^ Sahasranaman S, Howard D, Roy S (August 2008). "Clinical pharmacology and pharmacogenetics of thiopurines". Eur. J. Clin. Pharmacol. 64 (8): 753–67. doi:. PMID 18506437. http://dx.doi.org/10.1007/s00228-008-0478-6.
External links
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