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Thomas Sydenham

 
Britannica Concise Encyclopedia: Thomas Sydenham
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(born 1624, Wynford Eagle, Dorset, Eng. — died Dec. 29, 1689, London) British physician. His Observationes medicae (1676) was a standard textbook for two centuries, noted for its detailed observations and the accuracy of its records. His treatise on gout (1683) is considered his masterpiece. He was among the first to explain the nature of hysteria and St. Vitus dance (Sydenham chorea) and to use iron to treat iron-deficiency anemia. Sydenham also named scarlet fever and differentiated it from measles, first used laudanum (a solution of opium in alcohol) as a medication, and helped popularize the use of quinine for malaria.

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Encyclopedia of Public Health: Thomas Sydenham
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Thomas Sydenham (1624–1689) is often referred to as the English Hippocrates because of the emphasis, in his medical practice and teachings, of the importance of bedside observation. His writings, controversial in his day, condemned theorizing in medicine and taught that the understanding of disease and its treatment should be based on observation of the evolution of signs and symptoms in groups of patients over time, and on the observed responses of patients to medicines and treatments. His importance in public health stems principally from his interest in classifying febrile diseases and his study of epidemic patterns of fevers in London over many years. He concluded that febrile diseases were not merely idiosyncratic humoral responses to environmental stimuli, but distinct species of disease whose expression was greatly dependent on atmospheric and seasonal influences.

In treatment, Sydenham avoided the heavy use of drugs characteristic of his time, challenged prevailing approaches to the treatment of smallpox, and was a strong advocate of physical exercise and diet as therapy. He was perhaps the first influential physician to embrace Peruvian bark (quinine) in the treatment of ague (malaria), and one of the first to treat anemia with iron. In spite of his opposition to academic theorizing and experimental approaches in medicine, he was close to many of English scientists of the time, including Robert Boyle, Christopher Wren, Robert Hooke, and philosopher John Locke (also a physician), who was a devoted student of his medical teachings.

Sydenham's unconventional, even revolutionary, approach to medicine cannot easily be divorced from his involvement in the seventeenth-century Puritan rebellion against the British crown. The Sydenham family, Dorsetshire landowners, were strong supporters of Parliament and Cromwell in the English civil war of the 1640s. All five Sydenham brothers (Thomas was the youngest) and their father served as officers in Cromwell's rebel army. Thomas was wounded, two of his brothers were killed, their mother was murdered by Royalist troops, and the eldest brother, William, became a leading figure in Cromwell's protectorate. Sydenham's unpopularity with leading physicians during the period of Restoration in which he practiced may in part have been the consequence of his political history, as well as his lack of a full classical education, attributable to the interruption of his Oxford education by military service. His two major works, Methodis Curandis Febres (1666) and Observationes Medicae (1676), are thought to have been written in English and translated by a Latin scholar for publication.

Bibliography

Dewhurst, K. (1966). Dr. Thomas Sydenham (1624–1689): His Life and Original Writings. London: Wellcome Historical Medical Library.

— NIGEL PANETH


Biography: Thomas Sydenham
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The English physician Thomas Sydenham (1624-1689) emphasized, in practicing medicine, careful observation and experience and earned the title "English Hippocrates."

Born in Winford Eagle, Dorset, the fifth son of a wealthy country gentleman, Thomas Sydenham entered Magdalen College, Oxford, in 1642. His studies were interrupted by the outbreak of the civil war, during which the Sydenhams fought for the parliamentarians. He returned to Oxford in 1647, receiving his bachelor degree the following year. In 1651 he rejoined the army, after which he stayed at Oxford until 1663, when he was married and opened his London practice.

With only 18 months of formal medical education, consisting of a mixture of classics, anatomical dissections, and formal disputations, Sydenham found little use in theoretical learning, and experimental science seemed just as useless to him. He was convinced that only the careful observation of diseases at the bedside could lead to medical progress, and he spent all his efforts on detailed clinical observations. Despite his objection to theory and his insistence on a purely empirical medicine, he accepted the traditional concept that diseases resulted from disturbances of the bodily humors. He revived the Hippocratic notion that the seasons and atmospheric conditions played an equally important role, but he differed from Hippocrates in the emphasis he placed on the recognition of specific diseases. He believed that the detailed study of the natural history of any disease would eventually indicate what specific medication should be used for its treatment. Recognizing that Peruvian bark (crude quinine) was the only specific he knew, he prescribed it for malaria, which was the most prevalent fever in the London of his time.

At a time when most physicians were deeply concerned with theoretical questions, with systematization and attempts to relate medicine to experimental physics or chemistry, Sydenham's empiricism and emphasis on clinical description did not make him popular among his medical colleagues.

Some of Sydenham's writings became classics, like his description of gout (1683), which he suffered from for years and which ultimately led to his death. He differentiated scarlet fever from measles. His description of hysteria, which is frequently mentioned for its accuracy, included other conditions as well. The prevalence of smallpox led him to the conclusion that it was a physiological process which everyone had to go through. Because of his accurate portrayal of St. Vitus's dance, this disease became known as Sydenham's chorea. In therapy he insisted on simple prescriptions and measures, a fact which may have contributed to his great success as a practitioner.

His personal friend and fellow physician John Locke applied Sydenham's empiric medical ideas to philosophy. Succeeding generations of physicians found Sydenham's emphasis on bedside observation most useful and proclaimed him the "English Hippocrates." His emphasis on the study of the natural history of diseases and of all the factors surrounding their occurrence gave great impetus to the subsequent development of epidemiology.

Further Reading

A detailed biography, which also contains some of Sydenham's works in translation, is Kenneth Dewhurst, Dr. Thomas Sydenham, 1624-1689 (1966). Other studies are Joseph F. Payne, Thomas Sydenham (1900), and David Riesman, Thomas Sydenham, Clinician (1926). For background see Fielding H. Garrison, An Introduction to the History of Medicine (4th ed. repr. 1967).

 
Columbia Encyclopedia: Thomas Sydenham
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Sydenham, Thomas, 1624-89, English physician, called "the English Hippocrates." He studied at Oxford and Montpellier, and practiced in London. His conceptions of the causes and treatments of epidemics and his classic descriptions of gout, smallpox, malaria, scarlet fever, hysteria, and chorea established him as a founder of modern clinical medicine and epidemiology. He advocated direct observation instead of theorizing to determine the nature of disease and introduced the use of such drugs as cinchona bark (containing quinine) in treating malaria, and laudanum in treating other disorders.

Bibliography

See studies by J. F. Payne (1900) and D. Riesman (1926); K. Dewhurst, Dr. Thomas Sydenham, 1624-1689: His Life and Original Writings (1966).

Wikipedia: Thomas Sydenham
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Thomas Sydenham

Thomas Sydenham in a 1689 portrait by Mary Beale.
Born 10 September 1624(1624-09-10)
Wynford Eagle, Dorset
Died 29 December 1689 (aged 65)
Nationality English
Fields medicine
Known for clinical medicine

Thomas Sydenham (or Syndenham) (September 10, 1624 – December 29, 1689), was an English physician. He was born at Wynford Eagle in Dorset, where his father was a gentleman of property. His brother was Colonel William Sydenham. Thomas fought for the Parliament throughout the English Civil War, and, at its end, resumed his medical studies at Oxford. He became the undisputed master of the English medical world and was known as 'The English Hippocrates’. Among his many achievements was the discovery of a disease, Sydenham's Chorea, also known as St Vitus Dance.

Contents

Education

At the age of eighteen Sydenham was entered at Magdalen Hall, Oxford; after a short period his college studies appear to have been interrupted, and he served for a time as an officer in the Parliamentarian army during the English Civil War. He completed his Oxford course in 1648, graduating as bachelor of medicine, and about the same time he was elected a fellow of All Souls College. It was not until nearly thirty years later (1676) that he graduated as M.D., not at Oxford, but at Pembroke Hall, Cambridge,[1] where his eldest son was by then an undergraduate.

After 1648 he seems to have spent some time studying medicine at Oxford, but he was soon back in military service, and in 1654 he received the sum of 600, as a result of a petition he addressed to Oliver Cromwell, pointing out the various arrears due to two of his brothers who had been killed and reminding Cromwell that he himself had also faithfully served the parliament with the loss of much blood.

In 1655 he resigned his fellowship at All Souls and married, and probably a few years later went to study medicine at Montpellier. In 1663 he passed the examinations of the College of Physicians for their licence to practice in Westminster and 6 miles round; but it is probable that he had been settled in London for some time before that. This minimum qualification to practice was the single bond between Sydenham and the College of Physicians throughout the whole of his career.

He seems to have been distrusted by some members of the faculty because he was an innovator and something of a plain-dealer. In a letter to John Mapletoft he refers to a class of detractors "qui vitio statim vertunt si quis novi aliquid, ab illis non prius dictum vel etiam inauditum, in medium proferat" ("Who by a technicality suddenly turn if something is new, if someone should disclose something not previously said or heard"); and in a letter to Robert Boyle, written the year before his death (and the only authentic specimen of his English composition that remains), he says, "I have the happiness of curing my patients, at least of having it said concerning me that few miscarry under me; but [I] cannot brag of my correspondency with some other of my faculty .... Though yet, in taken fire at my attempts to reduce practice to a greater easiness, plainness, and in the meantime letting the mountebank at Charing Cross pass unrailed at, they contradict themselves, and would make the world believe I may prove more considerable than they would have me."

Sydenham attracted to him in warm friendship some of the most discriminating men of his time, such as Boyle and John Locke.

Works and innovations

Published works

His first book, Methodus curandi febres (The Method of Curing Fevers), was published in 1666; a second edition, with an additional chapter on the plague, in 1668; and a third edition, further enlarged and bearing the better-known title of Observationes medicinae (Observations of Medicine), in 1676. His next publication was in 1680 in the form of two Epistolae responsoriae (Letters & Replies), the one, "On Epidemics," addressed to Robert Brady, regius professor of physic at Cambridge, and the other "On the Lues venerea," (On [Venereal Diseases]) to Henry Paman, public orator at Cambridge and Gresham Professor of Physic in London.

In 1682 he published another Dissertatio epistolaris (Dissertation on the Letters), on the treatment of confluent smallpox and on hysteria, addressed to Dr William Cole of Worcester. The Tractatus de podagra et hydrope (The Management of [Arthritis] and [Dropsy]) came out in 1683, and the Schedula monitoria de novae febris ingressu (The Schedule of Symptoms of the Newly Arriven Fever)in 1686. His last completed work, Processus integri (The Process of Healing), is an outline sketch of pathology and practice; twenty copies of it were printed in 1692, and, being a compendium, it has been more often republished both in England and in other countries than any other of his writings separately. A fragment on pulmonary consumption was found among his papers. His collected writings occupy about 600 pages 8vo, in the Latin, though whether that or English was the language in which they were originally written is disputed.

Father of English medicine

Although Sydenham was a highly successful practitioner and saw, besides foreign reprints, more than one new edition of his various tractates called for in his lifetime, his fame as the father of English medicine, or the English Hippocrates, was decidedly posthumous. For a long time he was held in vague esteem for the success of his cooling (or rather expectant) treatment of small-pox, for his laudanum (the first form of a tincture of opium), and for his advocacy of the use of "Peruvian bark" in quartan agues, in modern terms, the use of quinine-containing chinchona bark for treatment of malaria caused by Plasmodium malariae. There were, however, those among his contemporaries who understood something of Sydenham's importance in larger matters than details of treatment and pharmacy, chief among them being the talented Richard Morton.

But the attitude of the academical medicine of the day is doubtless indicated in Martin Lister's use of the term sectaries for Sydenham and his admirers, at a time (1694) when the leader had been dead five years. If there were any doubt that the opposition to him was quite other than political, it would be set at rest by the testimony of Dr Andrew Brown, who went from Scotland to inquire into Sydenham's practice and has incidentally revealed what was commonly thought of it at the time, in his Vindicatory Schedule concerning the New Cure of Fevers. In the series of Harveian Orations at the College of Physicians, Sydenham is first mentioned in the oration of Dr John Arbuthnot (1727), who styles him "aemulus Hippocratis" ("rival of Hippocrates"). Hermann Boerhaave, the Leyden professor, was wont to speak of him in his class (which had always some pupils from England and Scotland) as "Angliae lumen, artis Phoebum, veram Hippocratici yin speciem" ("The light of England, the skill of Apollo, the truth of Hippocrates, and the visage of {?}"). A von Hailer also marked one of the epochs in his scheme of medical progress with the name of Sydenham. He is indeed famous because he inaugurated a new method and a better ethics of practice, the worth and diffusive influence of which did not become obvious (except to those who were on the same line with himself, such as Morton) until a good many years afterwards. It remains to consider briefly what his innovations were.

First and foremost he did the best he could for his patients, and made as little as possible of the mysteries and traditional dogmas of the craft. All the stories told of him are characteristic. Called to a gentleman who had been subjected to the lowering treatment, and finding him in a pitiful state of hysterical upset, he conceived that this was occasioned partly by his long illness, partly by the previous evacuations, and partly by emptiness. "I therefore ordered him a roast chicken and a pint of canary." A gentleman of fortune who was a victim to hypochondria was at length told by Sydenham that he could do no more for him, but that there was living at Inverness a certain Dr Robertson who had great skill in cases like his; the patient journeyed to Inverness full of hope, and, finding no doctor of the name there, came back to London full of rage, but cured withal of his complaint.

Of a piece with this is his famous advice to Sir Richard Blackmore. When Blackmore first engaged in the study of physic he inquired of Dr Sydenham what authors he should read, and was directed by that physician to Don Quixote, which, said he, "is a very good book; I read it still." There were cases, he tells us, in his practice where "I have consulted my patients' safety and my own reputation most effectually by doing nothing at all."

Nosology

It was in the treatment of smallpox that his startling innovations in that direction made most stir. It would be a mistake, however, to suppose that Sydenham wrote no long prescriptions, after the fashion of the time, or was entirely free from theoretical bias. Doctrines of disease he had, as every practitioner must have; but he was too much alive to the multiplicity of new facts and to the infinite variety of individual constitutions to aim at symmetry in his theoretical views or at consistency between his practice and his doctrines; and his treatment was what he found to cause it matches your eyes answer best, whether it were secundum artem ("Second skill") or not.

His fundamental idea was to take diseases as they presented themselves in nature and to draw up a complete picture (Krankheitsbild of the Germans) of the objective characters of each. Most forms of ill-health, he insisted, had a definite type, comparable to the types of animal and vegetable species. The conformity of type in the symptoms and course of a malady was due to the uniformity of the cause. The causes that he dwelt upon were the evident and conjunct causes, or, in other words, the morbid phenomena; the remote causes he thought it vain to seek after.

Acute diseases, such as fevers and inflammations. he regarded as a wholesome conservative effort or reaction of the organism to meet the blow of some injurious influence operating from without; in this he followed the Hippocratic teaching closely as well as the Hippocratic practice of watching and aiding the natural crises. Chronic diseases, on the other hand, were a depraved state of the humours, mostly due to errors of diet and general manner of life, for which we ourselves were directly accountable. Hence his famous dictum: "acutos dico, qui ut plurimum Deum habent authorem, sicut chronici ipsos nos" ("I say what hurts, most over which God has authority, just like we ourselves over the chronic").

Sydenham's nosological method is essentially the modern one, except that it wanted the morbid anatomy part, which was first introduced into the natural history of disease by Morgagni nearly a century later. In both departments of nosology, the acute and the chronic, Sydenham contributed largely to the natural history by his own accurate observation and philosophical comparison of case with case and type with type. The Observationes medicae and the first Epistola responsoria contain evidence of a close study of the various fevers, fluxes and other acute maladies of London over a series of years, their differences from year to year and from season to season, together with references to the prevailing weather, the whole body of observations being used to illustrate the doctrine of the epidemic constitution of the year or season, which he considered to depend often upon inscrutable telluric causes. The type of the acute disease varied, he found, according to the year and season, and the right treatment could not be adopted until the type was known.[2]

There had been nothing quite like this in medical literature since the Hippocratic treatise, (quote missing); and there are probably some germs of truth in it still undeveloped, although the modern science of epidemiology has introduced a whole new set of considerations. Among other things Sydenham is credited with the first diagnosis of scarlatina and with the modern definition, of chorea (in Sched. monit.). After small-pox, the diseases to which he refers most are hysteria and gout, his description of the latter (from the symptoms in his own person) being one of the classical pieces of medical writing. While Sydenham's natural history method has doubtless been the chief ground of his great posthumous fame, there can be no question that another reason for the admiration of posterity was that which is indicated by RG Latham, when he says, "I believe that the moral element of a liberal and candid spirit went hand in hand with the intellectual qualifications of observation, analysis and comparison."

Death

Hardly anything is known of Sydenham's personal history in London. He died at his house in Pall Mall on the 29th December 1689, aged 65. He is buried in St James's Churchyard, Piccadilly, where a mural slab was put up by the College of Physicians in 1810.

A memorial stone dedicated to Thomas can be found halfway up the staircase of St James's Church, Pall Mall. It was put there by the now defunct 'Sydenham Society’. The staff at the church are completely unaware of who he was.

Biographies

Among the lives of Sydenham are one (anonymous) by Samuel Johnson in John Swan's translation of his works (London, 1742), another by CG Kuhn in his edition of his works (Leipzig, 1827), and a third by Dr RG Latham in his translation of his works published in London by the Sydenham Society in 1848. See also Frédéric Picard, Sydenham, sa vie, ses œuvres (Paris, 1889), and JF Payne, T. Sydenham (London, 1900). Dr John Brown's Locke and Sydenham, in Hares subsecivae (Edinburgh, 1858), is of the nature of eulogy. Many collected editions of his works have been published, as well as translations into English, German, French and Italian. Dr WA Greenhill's Latin text (London, 1844, Syd. Soc.) is a model of editing and indexing. The most interesting summary of doctrine and practice by the author himself is the introduction to the 3rd edition of Observationes medicae (1676). A colleague, Dr John Browne described him as, 'the prince of practical medicine, whose character is as beautiful and as genuinely English as his name.

References

  • This article incorporates text from the Encyclopædia Britannica, Eleventh Edition, a publication now in the public domain.
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  1. ^ Sydenham, Thomas in Venn, J. & J. A., Alumni Cantabrigienses, Cambridge University Press, 10 vols, 1922–1958.
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