TNNT3

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Troponin T type 3 (skeletal, fast)
Identifiers
Symbols	TNNT3; AMCD2B; DA2B; FSSV; DKFZp779M2348
External IDs	OMIM: 600692 MGI: 109550 HomoloGene: 31405
Gene ontology Molecular function • protein binding • tropomyosin binding Cellular component • troponin complex Biological process • regulation of striated muscle contraction
Orthologs
Species	Human	Mouse
Entrez	7140	21957
Ensembl	ENSG00000130595	ENSMUSG00000061723
UniProt	P45378	Q9QZ47
RefSeq	NM_001042780 (mRNA)	NM_011620 (mRNA)
	NP_001036245 (protein)	NP_035750 (protein)
Location	Chr 11: 1.9 - 1.92 Mb	Chr 7: 142.31 - 142.33 Mb
PubMed search	[1]	[2]

Troponin T, fast skeletal muscle is a protein that in humans is encoded by the TNNT3 gene.^[1][2]

References

1. ^ Wu QL, Jha PK, Raychowdhury MK, Du Y, Leavis PC, Sarkar S (Jun 1994). "Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family". DNA Cell Biol 13 (3): 217-33. PMID 8172653. 
2. ^ "Entrez Gene: TNNT3 troponin T type 3 (skeletal, fast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7140. 

Further reading

• Chong PC, Hodges RS (1982). "Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions.". J. Biol. Chem. 257 (19): 11667–72. PMID 7118902. 
• Briggs MM, Maready M, Schmidt JM, Schachat F (1994). "Identification of a fetal exon in the human fast troponin T gene.". FEBS Lett. 350 (1): 37–40. doi:10.1016/0014-5793(94)00729-2. PMID 8062920. 
• Mao C, Baumgartner AP, Jha PK, et al. (1997). "Assignment of the human fast skeletal troponin T gene (TNNT3) to chromosome 11p15.5: evidence for the presence of 11pter in a monochromosome 9 somatic cell hybrid in NIGMS mapping panel 2.". Genomics 31 (3): 385–8. doi:10.1006/geno.1996.0064. PMID 8838323. 
• Jha PK, Leavis PC, Sarkar S (1997). "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system.". Biochemistry 35 (51): 16573–80. doi:10.1021/bi9622433. PMID 8987992. 
• Krakowiak PA, O'Quinn JR, Bohnsack JF, et al. (1997). "A variant of Freeman-Sheldon syndrome maps to 11p15.5-pter.". Am. J. Hum. Genet. 60 (2): 426–32. PMID 9012416. 
• Krakowiak PA, Bohnsack JF, Carey JC, Bamshad M (1998). "Clinical analysis of a variant of Freeman-Sheldon syndrome (DA2B).". Am. J. Med. Genet. 76 (1): 93–8. doi:10.1002/(SICI)1096-8628(19980226)76:1<93::AID-AJMG17>3.0.CO;2-K. PMID 9508073. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
• Hsiao CD, Tsai WY, Horng LS, Tsai HJ (2004). "Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish.". Dev. Dyn. 227 (2): 266–79. doi:10.1002/dvdy.10305. PMID 12761854. 
• Sung SS, Brassington AM, Krakowiak PA, et al. (2003). "Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B.". Am. J. Hum. Genet. 73 (1): 212–4. doi:10.1086/376418. PMID 12865991. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.". J. Mol. Biol. 350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID 15967462. 
• Chaudhuri T, Mukherjea M, Sachdev S, et al. (2005). "Role of the fetal and alpha/beta exons in the function of fast skeletal troponin T isoforms: correlation with altered Ca2+ regulation associated with development.". J. Mol. Biol. 352 (1): 58–71. doi:10.1016/j.jmb.2005.06.066. PMID 16081096. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 

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v • d • e Proteins of the cytoskeleton Human Microfilaments (ABPs) Myofilament Actins (A1, A2, B, G1, G2) Myosins (1A, 1B, 1C, MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, MYH16) Tropomodulin (1, 2, 3, 4) · Troponin (T 1 2 3, C 1 2, I 1 2 3) · Tropomyosin (1, 2, 3, 4) other related: Actinin (1, 2, 3, 4) · Arp2/3 complex · actin depolymerizing factors (Cofilin (1, 2) · Destrin) · Gelsolin · Profilin (1, 2) Other Wiskott-Aldrich syndrome protein IFs type 1 and 2 (Cytokeratin, type I, type II) · type 3 (Desmin, GFAP, Peripherin, Vimentin) · type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) · type 5 (Lamin A, B) Microtubules Dyneins · Kinesins · MAPs (Tau protein, Dynamin) · Tubulins · Stathmin · Tektin Catenins Alpha catenin · Beta catenin · Plakoglobin (gamma catenin) · Delta catenin Other APC · Dystrophin (Dystroglycan) · plakin (Desmoplakin, Plectin) · Spectrin (SPTA1, SPTAN1, SPTB, SPTBN1, SPTBN2, SPTBN4, SPTBN5) · Talin (TLN1)  · Utrophin · Vinculin Nonhuman Major sperm proteins · Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)

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