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Tolterodine

 
Drug Info: Tolterodine

Brand names: Detrol®Detrol® LA

Chemical formula:



Tolterodine tablets or extended-release capsules

What are tolterodine tablets or extended-release capsules?

TOLTERODINE (Detrol® tablets and Detrol® LA extended-release capsules) help to control an overactive bladder, a chronic condition that can be improved with medication. Tolterodine may reduce the frequency of bathroom visits and may help to control wetting accidents. Generic tolterodine tablets and capsules are not yet available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• difficulty passing urine
• glaucoma
• intestinal obstruction
• kidney disease
• liver disease
• stomach problems like pyloric stenosis or reflux, or other problems with proper emptying of the contents of the stomach
• an unusual or allergic reaction to tolterodine, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take tolterodine tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If you are taking the extended-release capsules, swallow them whole, do not crush, cut, or chew. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What drug(s) may interact with tolterodine?

• alcohol-containing beverages
atropine
bosentan
caffeine
cisapride
clarithromycin
cyclosporine
diltiazem
erythromycin
fluvoxamine
• grapefruit juice
hyoscyamine
• medicines for fungal infections, like fluconazole, itraconazole, ketoconazole or voriconazole
• medicines for treating HIV infection or AIDS
metoclopramide
nefazodone
norfloxacin
omeprazole
• oxybutinin
quinidine
quinine
scopolamine
tegaserod
• troleandomycin
verapamil
vinblastine
warfarin
• water pills (diuretics)
zafirlukast

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before stopping or starting any of your medicines.

What should I watch for while taking tolterodine?

It may take 2 or 3 months to notice the maximum benefit from this medication. Your health care professional may also recommend techniques that may help improve control of your bladder and sphincter muscles. Such techniques will help train you to need the bathroom less frequently.

You may need to limit your intake tea, coffee, caffeinated sodas, and alcohol; these drinks may aggravate your symptoms. Keeping healthy bowel habits may lessen bladder symptoms. If you currently smoke, quitting smoking may help reduce irritation to the bladder muscle.

You may get dizzy or have blurred vision. Do not drive, use machinery, or do anything that requires mental alertness until you know how tolterodine affects you.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water, will help.

Tolterodine may cause dry eyes and blurred vision. If you wear contact lenses, you may feel some discomfort. Lubricating drops may help. See your ophthalmologist if the problem does not go away or is severe.

What side effects may I notice from using tolterodine?

Serious side effects are not common. Side effects that you should report to your doctor as soon as possible:
• any signs of an allergic reaction, like itching or hives
• blurred vision or difficulty focusing vision
• confusion
• difficulty passing urine
• severe dizziness

Side effects that usually do not require medical attention (report to your doctor if they continue or are bothersome):
• constipation
• dry eyes
• dry mouth
• headache
• mild dizziness or drowsiness
• indigestion or stomach discomfort

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Wikipedia: Tolterodine
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Tolterodine
Systematic (IUPAC) name
(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
Identifiers
CAS number 124937-51-5
ATC code G04BD07
PubChem 60774
DrugBank APRD00146
Chemical data
Formula C22H31NO 
Mol. mass 325.488 g/mol
Pharmacokinetic data
Bioavailability 77%
Protein binding Approximately 96.3%.
Metabolism  ?
Half life 1.9-3.7 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?
 Yes check.svgY(what is this?)  (verify)

Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade names Detrol and Detrusitol.

Pharmacology

Tolterodine acts on M1, M2, M3, M4 and M5 subtypes of muscarinic receptors whereas modern antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective. It is marketed and manufactured by Pfizer.

Tolterodine, although it acts on all types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (M3 and M1 selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.

Side effects

Known Side Effects:

Reports of Patients’ Experiences Since Detrol Became Available:

The following reactions have been reported in patients who have taken Detrol since it has become available:

Contraindications:
Not to be used in patients with Myasthenia Gravis and Angle Closure Glaucoma

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Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Tolterodine" Read more