Toxic Shock Syndrome Toxin (TSST) is a superantigen with a size of 22KDa [1]produced by somewhere between 5% and 25% of Staphylococcus aureus isolates. It causes toxic shock syndrome by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumour necrosis factor. In general, the toxin is not produced by bacteria growing in the blood; rather, it is produced at the local site of an infection, and then enters the blood stream.
It crosslinks the TCR peptide chain with the peptide chain of the MHC-class II molecule.(DR. Mrugesh K Patel)
References
- ^ Dinges MM, Orwin PM, Schlievert PM (January 2000). "Exotoxins of Staphylococcus aureus". Clin. Microbiol. Rev. 13 (1): 16–34. PMID 10627489. PMC 88931. http://cmr.asm.org/cgi/pmidlookup?view=long&pmid=10627489.
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