n.
A plasma globulin that binds hydrocortisone and related corticosteroids. Also called corticosteroid-binding globulin.
Transcortin
| Medical Dictionary: trans·cor·tin |
(trăns-kôr'tn, trănz-)
n.
n.
| 5min Related Video: Transcortin |
| Veterinary Dictionary: transcortin |
An α-globulin that binds and transports biologically active, unconjugated cortisol in plasma.
| Wikipedia: Transcortin |
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin | |
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| Structure of corticosteroid-binding globulin in complex with cortisol. | |
| Identifiers | |
| Symbol | SERPINA6 |
| Alt. symbols | CBG |
| Entrez | 866 |
| HUGO | 1540 |
| OMIM | 122500 |
| RefSeq | NM_001750 |
| UniProt | P08185 |
| Other data | |
| Locus | Chr. 14 q32.1 |
Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.
It is an alpha-globulin.
Binding
Transcortin binds several steroid hormones:
- Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.
- Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.
Production
Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
External links
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Learn More
 | corticosteroid |
| plasma |
| Thyroxine-binding proteins |
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Copyrights:
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 | Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Read more |
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| Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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| Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Transcortin". Read more |
