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| Systematic (IUPAC) name | |
|---|---|
| (RS)-2,2,2-trichloro-1-dimethoxyphosphoryl-ethanol | |
| Identifiers | |
| CAS number | 52-68-6 |
| ATC code | P02BB01 QP52 QP53 |
| PubChem | 5853 |
| Chemical data | |
| Formula | C4H8Cl3O4P |
| Mol. mass | 257.436 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
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Metrifonate (INN) or trichlorfon (USAN) is an organophosphate acetylcholinesterase inhibitor.
It is classified as irreversible.[1]
It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.[2]
It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.[3]
References
- ^ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease". http://www.library.nhs.uk/neurological/ViewResource.aspx?resID=237789.
- ^ "Schistosomiasis". 2002. pp. 1212–1220. http://content.nejm.org/cgi/reprint/346/16/1212.
- ^ López-Arrieta J, Schneider L (2008). "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:.
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