Triprolidine

Triprolidine

Systematic (IUPAC) name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridine
Identifiers
CAS number	486-12-4
ATC code	R06AX07
PubChem	5282443
DrugBank	APRD00306
Chemical data
Formula	C19H22N2
Mol. mass	278.391 g/mol
SMILES	eMolecules & PubChem
Physical data
Melt. point	60 °C (140 °F)
Solubility in water	500 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability	4% oral
Protein binding	90%
Metabolism	Hepatic (CYP2D6)
Half life	4 to 6 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	C (US)
Legal status	OTC (US)
Routes	Oral
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Triprolidine hydrochloride is an over-the-counter antihistamine. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many over-the-counter antihistamines, the most common side effect is drowsiness. Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15-30 minutes.

Trade names

• Actidil
• Myidil
• Actifed (as a combination with pseudoephedrine)

Note: in some countries (Belgium e.g.), ACTIFED contains pseudoephedrine and triprolidine, but the same pharmaceutical company (GSK) has introduced an "ACTIFED New" which contains dextromethorphan hydrobromide, an anti-tussive compound unrelated to pseudoephedrine and triprolidine, and with different indications (symptomatic treatment of non-productive, irritative cough).

Note: Actifed CC tablets no longer available for sale in Australia due to people buying large quantities to convert into illegal recreational drugs due to the ease of extraction.

External links

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