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It has been suggested that this article or section be merged with Amine_N-methyltransferase. (Discuss) |
Tryptamine N-methyltransferase (alternative names: indolethylamine N-methyltransferase (INMT), amine N-methyltransferase, arylamine N-methyltransferase, nicotine N-methyltransferase) is an enzyme which is ubiquitously present in non-neural tissues and which catalyzes the N-methylation of tryptamine and structurally related compounds[1]. In the case of tryptamine and serotonin these then become the dimethylated indolethylamines dimethyltryptamine (DMT) and bufotenine.[2]
The chemical reaction taking place is:
- S-adenosyl-L-methionine + an amine <==> S-adenosyl-L-homocysteine + a methylated amine
A wide range of primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variery of drugs and other xenobiotics.[1]
See also
References
- ^ a b MeSH tryptamine+N-methyltransferase
- ^ J., Kärkkäinen; T. Forsström; J. Tornaeus; K. Wähälä; P. Kiuru; A. Honkanen; U. -H. Stenman; U. Turpeinen; A. Hesso (April 2005). "Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues". Scandinavian Journal of Clinical and Laboratory Investigation 65 (3): 189–199. doi:. http://www.informaworld.com/smpp/content~content=a713735722~db=all~order=page. Retrieved on October 15, 2008.
External links
- EC 2.1.1.49
- Lyon ES, Jakoby WB (1981). "Arylamine N-methyltransferase". Meth. Enzymol. 77: 263–6. doi:. PMID 6276654.
- Boarder MR, Rodnight R (1976). "Tryptamine-N-methyltransferase activity in brain tissue: a re-examination". Brain Res. 114 (2): 359–64. doi:. PMID 963555.
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