| TNFR/NGFR cysteine-rich region | ||
|---|---|---|
| Identifiers | ||
| Symbol | TNFR_c6 | |
| Pfam | PF00020 | |
| InterPro | IPR011614 | |
| PROSITE | PDOC00561 | |
| SCOP | 1tnr | |
| Available PDB structures: | ||
A tumor necrosis factor receptor (TNFR), or death receptor, is a cytokine receptor that binds tumor necrosis factors (TNF).
Because "TNF" is often used to describe TNF alpha, "TNFR" is often used to describe the receptors that bind to TNF alpha - namely, CD120. However, there are several other members of this family that bind to the other TNFs.[1][2]
Contents |
Members
Family members include:[1]
| Type | Protein | Aliases | Gene |
|---|---|---|---|
| 1 (CD120) | CD120a | TNFRSF1A | |
| CD120b | TNFRSF1B | ||
| 3 | Lymphotoxin β receptor | TNFRSF3 | LTBR |
| 4 | CD134 | TNFRSF4 | |
| 5 | CD40 | TNFRSF5 | CD40 |
| 6 | FAS | TNFRSF6 | FAS |
| TNFRSF6B | TNFRSF6B | ||
| 7 | CD27 | TNFRSF7 | CD27 |
| 8 | CD30 | TNFRSF8 | |
| 9 | CD137 | TNFRSF9 | |
| 10 | TNFRSF10A | TNFRSF10A | |
| TNFRSF10B | TNFRSF10B | ||
| TNFRSF10C | TNFRSF10C | ||
| TNFRSF10D | TNFRSF10D | ||
| 11 | RANK | TNFRSF11A | |
| Osteoprotegerin | TNFRSF11B | ||
| 12 | TNFRSF12A | TNFRSF12A | |
| 13 | TNFRSF13B | TNFRSF13B | |
| TNFRSF13C | TNFRSF13C | ||
| 14 | TNFRSF14 | TNFRSF14 | |
| 16 | TNFRSF16 | NGFR | |
| 17 | TNFRSF17 | TNFRSF17 | |
| 18 | TNFRSF18 | TNFRSF18 | |
| 19 | TNFRSF19 | TNFRSF19 | |
| 21 | TNFRSF21 | TNFRSF21 | |
| 25 | TNFRSF25 | TNFRSF25 | |
| 27 | Ectodysplasin A2 receptor | TNFRSF27 | EDA2R |
References
- ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:. PMID 11239407.
- ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:. PMID 15819693.
Further reading
- Kavurma MM, Tan NY, Bennett MR. (2008). "Death receptors and their ligands in atherosclerosis". Arterioscler Thromb Vasc Biol. 28 (10): 1694–702. doi:. PMID 18669890.
- Hatano, E. (2007). "Tumor necrosis factor signaling in hepatocyte apoptosis.". J Gastroenterol Hepatol. 22: S43–44. doi:. PMID 17567463.
External links
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