| U12 minor spliceosomal RNA | ||||||||||
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U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.[1] The predicted secondary structure of U12 RNA is published,[2] but the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences.[3]
References
- ^ Tarn, WY; Steitz JA (1997). "Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge". Trends Biochem Sci 22: 132–137. doi:. PMID 9149533.
- ^ Shukla, GC; Padgett RA (1999). "Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants". RNA 5: 525–538. doi:. PMID 10199569.
- ^ Otake, LR; Scamborova P, Hashimoto C, Steitz JA (2002). "The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila". Mol Cell 9: 439–446. doi:. PMID 11864616.
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