| Meaning | Category |
| Sierra Generations Family File | Computing->File Extensions |
| Ultimate Death Squad | Governmental->Military |
| Ultramar Diamond Shamrock Corporation | Business->NYSE Symbols |
| Unit Data System | Governmental->Military |
| Universal Data Server | Computing->Software |
| Universal Datacom System | Computing->Networking |
| Universal Directory Service | Computing->Telecom |
| Universal Documentation System | Governmental->NASA |
| Universal Documentation Systems | Business->Firms |
| University Dining Services | Academic & Science->Universities |
| Unión Democrática de Soldados | Governmental->Politics |
| Urban Death Squad | Community->Law |
| Urine Drug Screen | Medical->Laboratory |
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