Hans Krebs and Kurt Henseleit in 1932

Gene Therapy cannot treat

· Phenylketonuria

· Gaucher Disease

· Lesch-Nyhan Syndrome

· Urea Cycle Disorders

· Duchenne Muscular Dystrophy

ammonium ion, which is the end product of amino acid degradation, is toxic if allowed to accumulate. the urea cycle is a pathway that detoxifies the ammonium ions by converting it to urea - which is then transported to the kidneys to form urine... the function is to remove nitrogen waste from the body and avoid toxicity

fumarate

Ornithine