| Meaning | Category |
| Mabaruma, Guyana | Regional->Airport Codes |
| U S Industries, Inc. | Business->NYSE Symbols |
| Un Satisfactory Inspection | Governmental->Military |
| Unified Space Intelligence | Governmental->Military |
| United Systems Institute | Academic & Science->Universities |
| Unitray Systems, Inc. | Business->Firms |
| Universal Serial Interface | Computing->Hardware |
| Universal Systems, Inc. | Business->Firms |
| University of Southern Indiana ( Evansville) | Academic & Science->Universities |
| Update Software Identity | Governmental->NASA |
| User System Interface | Governmental->Military Computing->Telecom |
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