VSD may refer to:
- Vaccine Safety Datalink, a Centers for Disease Control database containing vaccination and health records of over 7 million Americans
- Variable speed drive, or adjustable-speed drive, is a specific type of a variable frequency drive
- VSD (Vendredi Samedi Dimanche; i.e. "Friday Saturday Sunday"), a French weekly news magazine
- ventricular septal defect, a defect in the ventricular septum of the heart
- Video Single Disc, a video disc format based on laserdisc that only was popular in Japan and the rest of Asia
- Virtually safe dose, a concept in regulatory toxicology, applied to carcinogens with no threshold of effects
- File extension for Microsoft Office Visio drawings
- Voltage-sensing domain, membrane protein domain which is affected by voltage alterations over the membrane
- Visible surface determination, also known as Hidden surface determination
- A Victory Star Destroyer from the Star Wars universe.
- Valstybės saugumo departamentas - Security department of the State in Lithuania.
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