weariness

The quality or state of being weary or tried; lassitude; exhaustion of strength; fatigue.

With weariness and wine oppressed.

A man would die, though he were neither valiant nor miserable, only upon a weariness to do the same thing so oft over and over.

noun

1. The condition of being extremely tired: exhaustion, fatigue, tiredness. See tired/fresh.
2. A lack of excitement, liveliness, or interest: asepticism, blandness, colorlessness, drabness, dreariness, dryness, dullness, flatness, flavorlessness, insipidity, insipidness, jejuneness, lifelessness, sterileness, sterility, stodginess, vapidity, vapidness. See excite/bore/interest.

The noun has one meaning:

Meaning #1: temporary loss of strength and energy resulting from hard physical or mental work
  Synonyms: fatigue, tiredness