Vertebrate Has a BACKBONE and Invertebrate Doesn't have a BACKBONE

The most significant difference between a vertebrate and an invertebrate is that a vertebrate has a spine and an invertebrate doesn't.

a vertebrate is an animal with a backbone an invertebrate is one with no backbone

The main difference is that a vertebrate is an animal that does have

a backbone or spine. An invertebrate does not have a backbone or spine.

Vertibrates have bones while invertibrate don't have.