William Henry may refer to:
- William Henry (delegate) (1729–1786), American gunsmith and Pennsylvania delegate to Continental Congress
- William Henry (brother of Patrick Henry) (1735–1785), representative in the House of Burgesses
- William Henry (chemist) (1775–1836), English chemist who formulated Henry’s law
- William Henry (congressman) (1788–1861), United States Congressman from Vermont
- William Alexander Henry (1816–1888), justice of the Canadian Supreme Court
- William Henry (swimmer) (1859–1928), British swimmer
- William Henry (actor) (1914–1982), United States movie actor
- William Henry (historian), Irish historian
- William A. Henry III (1950–1994), United States author and cultural critic
- William Thomas Henry, politician in Alberta, Canada and member of the Legislative Assembly of Alberta
- William "Bill" Rodman Henry, known as Bill Henry, Major League baseball player
- William W. Henry (1831–1915), Medal of Honor recipient
- William "Jerry" Henry, a fugitive slave in Syracuse, New York in the United States who was arrested and freed in an event known as the Jerry Rescue
- Prince William Henry, Duke of Gloucester and Edinburgh, a member of the British Royal Family and a younger brother of King George III
Other:
- William III of England, sometimes known as William Henry, Prince of Orange
- William IV of England, known as William Henry, Duke of Clarence before he became king
Place:
- William Henry, original name for the town of Sorel, Quebec
- Fort William Henry, the British fort built in upper New York during the French & Indian War, 1754–1763; immortalized in James Fenimore Cooper's Last of the Mohicans
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