William Standish Knowles
| William Standish Knowles | |
|---|---|
| Born | June 1 1917 Taunton, Massachusetts, United States |
| Nationality | 
American |
| Field | Chemist |
| Known for | Chiral phosphine ligands that proved effective in the enantioselective synthesis of L-DOPA |
| Notable prizes | Nobel Prize in Chemistry (2001) (jointly with Ryoji Noyori and K. Barry Sharpless) |
William S. Knowles (born June 1, 1917) is an American chemist. He was born in Taunton, Massachusetts.
He shared the Nobel Prize in Chemistry in 2001 with Ryoji Noyori and K. Barry Sharpless for the development of catalytic asymmetric synthesis, which is a technology relevant to the preparation of many pharmaceuticals. Knowles led a team of researchers that developed chiral phosphine ligands that proved effective in the enantioselective synthesis of L-DOPA.[1][2] Knowles conducted this prize-winning research at Monsanto.
He currently resides in St. Louis, Missouri.
References
- ^ Vineyard, B. D.; Knowles, W. S.; Sabacky, M. J.; Bachman, G. L.; Weinkauff, D. J. "Asymmetric Hydrogenation. Rhodium Chiral Bisphosphine Catalyst" Journal of the American Chemical Society 1977, volume 99, pages 5946-5952.
- ^ Knowles, W. S. “Asymmetric Hydrogenations (Nobel Lecture)” Angewandte Chemie International Edition 2002, Volume 41, pages 1998 - 2007. DOI: 10.1002/1521-3773(20020617)41:12<1998::AID-ANIE1998>3.0.CO;2-8.
| Nobel Prize in Chemistry Laureates |
|---|
|
William Knowles / Ryoji Noyori / K. Barry Sharpless (2001) • John B. Fenn / Koichi Tanaka / Kurt Wüthrich (2002) • Peter Agre / Roderick MacKinnon (2003) • Aaron Ciechanover / Avram Hershko / Irwin Rose (2004) • Robert H. Grubbs / Richard R. Schrock / Yves Chauvin (2005) • Roger D. Kornberg (2006) • Gerhard Ertl (2007) |
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Complete roster | (1901–1925) | (1926–1950) | (1951–1975) | (1976-2000) | (2001–2025) |
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