Witebsky's postulates are a series of criteria developed by Ernst Witebsky used to determine if a condition could be considered autoimmune.[1]
Modern revisions consider three types of evidence:
- direct evidence from transfer of pathogenic antibody or pathogenic T cells
- indirect evidence based on reproduction of the autoimmune disease in experimental animals, and
- circumstantial evidence from clinical clues.
See also
References
- ^ van Gaalen F, Ioan-Facsinay A, Huizinga TW, Toes RE (November 2005). "The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis". J. Immunol. 175 (9): 5575–80. PMID 16237041. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16237041.
Further reading
- Rose NR, Bona C (September 1993). "Defining criteria for autoimmune diseases (Witebsky's postulates revisited)". Immunol. Today 14 (9): 426–30. doi:. PMID 8216719.
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