Conditions and Diseases

'transformation of normal cell into cancer cell'?

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Wiki User
March 04, 2008 8:59PM

The most fundamental way to transform a normal cell is to

overexpress two key proto-oncogenes: c-Myc and Ras. In tandem, it

is necessary to downregulate the potent sentinel of the cell: p53.

Other additional changes can be made to enhance the transformation

such as manipulating certain growth factor receptors, cell cycle

regulators, and anti-apoptotic proteins.

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