'transformation of normal cell into cancer cell'?
The most fundamental way to transform a normal cell is to
overexpress two key proto-oncogenes: c-Myc and Ras. In tandem, it
is necessary to downregulate the potent sentinel of the cell: p53.
Other additional changes can be made to enhance the transformation
such as manipulating certain growth factor receptors, cell cycle
regulators, and anti-apoptotic proteins.