The first place to start looking is the spark plug wires. They can be checked with an ohm meter. Rule of thumb is 5000 ohms per foot of wire.
this is most likely a bad injector. Try a tank of premium gas and Lucas injector cleaner. If it still misses, you probably need to change an injector.
You need to check compression on #6.
Low compression in a cylinder, a burnt valve, loose plug or plug wire, bad injector, bad electronics.
Too rich of an air/fuel mixture of one of more cylinders missing and not completely burning the fuel.
Yes it can if one or more cylinders is missing. Those cylinders are wasting fuel.
could need a tune up or you could have a bad fuel injector
Missing and backfiring are a sure sighn the timing is out. Check and make sure you put all the plug wires back in the proper position.
Remove all the plugs and do a compression test on all cylinders. If compression is good then replace all plugs and plug wires one at a time. If you find one or more cylinders with low compression, suspect a burnt valve, or a possible blown head gasket, especially if you are loosing coolant. You may also have an injector that is malfunctioning. Start with the plugs and wires which probably need replacing anyway.
Like a V-6 engine, missing on two cylinders. kapm
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The pistons will be working all the time because they are attached to the crank shaft. This makes it impossible for them to not work. They could, however, be missing, which can be caused by lack of fuel. All that needs to be done is removing the fuel line to the injector. Then, crank the engine and see if fuel squirts out. That'd be a good place to start.