82 s10 that Im putting a 350 in what type of transmission and rear end are best to put in?

If you are using an automatic, the TH 350 with a shift kit is a wonderful and stout choice. The rear end is a bit more wide open. If you are looking for a posi rear end the GM 12 bolt can be made to fit, or the Ford 9 inch is a favorite. If the S-10 had a v6 you might be able to leave the stock rear end in until it burns out. You might also look for a rear end from a newer S10 that has a 4.3 engine, as they should handle things alright without having to have the rear end modified to fit the truck.