Missense mutation
Nonsense mutation
Frameshift insertion
Frameshift deletion
All may cause antibiotic resistance in bacteria
The bacteria benefits.
A random mutation causes one bacterium to become resistant to an antibiotic. Then all the others are killed when the antibiotic is introduced to the environment. The mutated bacterium is free to reproduce and soon many members of that species are resistant to that antibiotic.
harmful mutation
The forces that affect bacteria population are competition, mutation and selection, just like any other population affected by the theory of evolution. In a large population of bacteria, some individuals will be mutated to have resistance to antibiotic drugs (or any other drug). This is a disadvantage to the individual as long as there is no antibiotic drug in the surroundings. In this case there is mutation but no selection. When an antibiotic drug is given to a patient, selection is being done in the evolutionary aspect of the bacteria. Only the drug-resistant mutants survive, since the selection does not affect them. All the non-mutant bacteria die; the mutants have no competition, and can flourish undisturbed.
Why is the human body resistant to antibiotics? Because synthetic medicines tend to be quite simple, the bacteria that should be affected by the antibiotic are able to build a defense against it.
Microevolution
mutation that causes resistance
Not all mutations are harmful. A mutation the give the organism antibiotic resistance, for example, is quite helpful. A different mutation that causes a necessary protein to misfold may result in death. In general mutations that affect proteins that are necessary for life will result in the death of the organism. One such mutation is in the protein p53 which is necessary to prevent a cell from growing uncontrollable (cancer). A mutation in p53 could result in a cell with damaged DNA to reproduce - this is what we call cancer.
In every organism, there are differences between individuals. For example, hair color in humans. Bacteria and viruses, being so small, mutate much quicker than humans. One of the individual traits of a virus or bacteria can be resistance to a drug or antibiotic. So as the drug is used, the organisms without the resistance die off while the resistant individuals live. The resistant individuals reproduce, and pass on this resistance to their offspring. Thus, the population increases once again, but this time, all the organisms have the resistance. This is shown clearly with the antibiotics we use, which only stay effective for fighting diseases for 20 to 60 years. After this time, most of the bacteria has mutated to be resistant to the antibiotic, and so will no longer be killed by it.
There is no single type of mutation that causes Hemophilia A. It is not the type of mutation but rather the location of the mutation within the genetic code.
When antibiotics are given, most of the resident bacteria are killed. With fewer bacteria to compete with, the normally harmless Clostridia difficile grow rapidly and produce toxins.
Some pathogen bacteria are:Escherchia coli - Causes stomach upsets.Staphylococcus aureus - the antibiotic resistant version of this organism is called MRSA and causes problems for patients in hospital.Clostridium difficile - another stomach upset causer