Medication and Drugs

Advantage of effervescent tablets?

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2012-10-15 03:24:50
2012-10-15 03:24:50

1. Fast onset of action

Effervescent tablets have major advantage that the drug product is already in solution at the time it is consumed. Thus, the absorption is faster and more complete than with conventional tablet. This is particularly helpful in treating acute symptoms of pain. Faster absorption means faster onset of action, critical in treating acute symptoms such as pain. Buffered preparations with adjustable stomach pH optimize formula performance characteristics.

Effervescent drugs are delivered to the stomach at a pH that is just right for absorption. Many medications travel slowly through the gastrointestinal tract or have absorption that is hampered by food or other drugs. To achieve desired absorption levels, such drugs have to be often administered as injections or with increased dosages.

2. No need to swallow tablets

Effervescent medications are administered in liquid form so they are easy to take as compared to tablets or capsules. The number of people who cannot swallow tablets or who dislike swallowing tablets and capsules is growing. Many diseased conditions require the patient or customer to swallow several tablets at a time. The elderly, in particular, have difficulty in swallowing tablets. With an effervescent dosage form, one dose can usually be delivered in just 3 or 4 ounces of water. The amount used when someone swallows a conventional tablet or capsule.

3. Good stomach and intestinal tolerance

Effervescent tablets dissolve fully in a buffered solution. Reduced localized contact in the upper gastrointestinal tract leads to less irritation and greater tolerability. Buffering also prevents gastric acids from interacting with the drugs themselves, which can be a major cause of stomach and esophageal upsets.

4. More portability

Effervescent tablets are more easily transported than liquid medication because no water is added until it's ready to use.

5. Improved palatability

Drugs delivered with the effervescent base, taste better than most liquids, mixtures and suspensions. Superior taste masking is achieved by limiting objectionable characteristics and complementing formulations with flavors and fragrances. Effervescent pharmaceuticals retain their flavor after lengthy storage. The effervescent tablets essentially include flavorings so they taste much better than a mixture of a non-effervescent powder in water. Moreover, they produce fizzy tablets, which may have better consumer appeal than the traditional dosage forms.

6. Superior stability

Excellent stability is inherent with effervescent formulations, particularly surpassing liquid forms.

7. More consistent response

Drugs delivered using effervescent technology have predictable and reproducible pharmacokinetic profiles that are much more consistent than tablets or capsules.

8. Incorporation of large amounts of active ingredients

In many cases, one effervescent tablet will equal to three conventional tablets in active dose amounts.

9. Accurate dosing

Researchers have shown that effervescent tablets enhance the absorption of a number of active ingredients (e.g. disulfiram and caffeine), compared to conventional formulations. This is because the carbon dioxide created by the effervescent reaction can induce enhanced active-ingredient permeability due to an alteration of the paracellular pathway. The paracellular pathway is the primary route of absorption for hydrophilic active ingredients in which the solutes diffuse into the intercellular space between epithelial cells. It is postulated that the carbon dioxide widens the intercellular space between cells, which leads to greater absorption of active ingredients (both hydrophobic and hydrophilic). The increased absorption of hydrophobic active ingredients could be due to the non-polar carbon dioxide gas molecules partition into the cell membrane, thus creating an increased hydrophobic environment, which would allow the hydrophobic active ingredients to be absorbed.

10. Improved therapeutic effect

The effervescent components aid in improving the therapeutic profiles of the active ingredients. They also help in solubilization of poorly soluble drugs.

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