Poisons and Toxins
An altered toxin that has lost its ability to harm but keeps its antigenicity?
Asked in Poisons and Toxins
What is the name of the toxin that has been altered so that is harmless yet still antigenic?
Asked in Biology, Poisons and Toxins
What type of biological agent acts to destroy an organism by overwhelming the organism's ability to rid itself of the poison it produces?
Asked in Vaccinations
How do toxoid is formed?
PREPARATION OF TOXIN FIRST;suitable strain of microbes is taken and inoculated in sterile agar and is incubated till sufficient amount of toxin been produced. then with a help of filtering materials such as ceramic filters are taken and bacteria along with its media containing toxin is allowed to filtered.then bacteria retain on filter while toxin along with media is collected as a filtrate. thus this is again sterilized to remove any spores or unwanted metabolites present in media .this can be done due to solubility nature of exotoxin in water.this favours separation of toxin from bacteria. PREPARATION OF TOXOID;then the sterilized toxin is mixed with the 25%HCHO and is incubated for 2-6 weeks.then all the toxicity of toxoid will be gone.but antigenicity property will remain as alike which is very important feature required for vaccines. this toxoid prepared can be used as a such or further modified to still purer forms to prevent dangerous side effects caused in adults due to presence of unwanted metabolites of microbes.
Does immunization with an altered form of tetanus toxin provide artificially acquired active or passive immunity?
toxoid;it is nothing but the reduced or inactive form of toxin .it is nothing but the vaccine. altered FORM for toxins are nothing but the TOXIODS,TOXIOD-ANTITOXIN FLOCCULES,ALUM PRECIPITATED TOXOIDS,PURIFIED AMMONIUM PHOSPHATE ,ETC. ALL these altered form of toxins contains reduced or inactive form of microorganisms or their products.these act as antigens in our body and thus they contain mainly antigenecity property. if antigen containing preparations are introduced into our body we acquire active immunity. as it is artificially acquired we attain finally ARTIFICIALLY ACQUIRED ACTIVE IMMUNITY. there are some preparation which causes passive immunity .these contain only antibodies.hence this immunity will not last lonf for life time.EX;sera containing preparations such as human immuno sera ,horse sera,tetanus antitoxin,diphytheria antitoxin,etc. hence immunisation with altered form of tetanus toxin will provide artificially acquired active immunity which last longs for life time for that specific antigen clostridium tetani organism or for its toxin. alterd forms of various toxins are available in market in names of toxoids or neutralised floccules,etc.