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"The Simpsons" and "Family Guy" are cartoon shows and therefore it is impossible for them to be friends.

Assuming you mean the creators, the answer is Yes.

Seth MacFarlane & Matt Groening have both have stated in interviews they are friends.

I'm sure they aren't hanging out drinking together but they are friends in a professional mutual respect sort of way.

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Q: Are The Simpsons and Family Guy friends?
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