Are there any known descendants of Muhammad?
There are none in the direct line, since he had no surviving sons; however, there are many who claim descent through his daughters.
They are related in a couple of ways: Both were descendants of Noah's son Shem. Both were descendants of Abraham. After that we are unsure, but it is most likely the Muhammad was a descendant of Ishmael, Abraham's son by Sarah's maidservant Hagar, 13 years older than Issac. Jesus was a descendant of Issac. So it is a very distant relation, since all living humans are descendants of Noah too.
Prophet Abraham (PBUH) has two sons; prophets Isaac and Ismael (Peace be upon them). From prophet Isaac the descendants Jacob then Joseph and Jesus and others (Peace be upon them). From Ismael (or Ishmael) are the descendants ending with prophet Muhammad (PBUH). Answer: From Abraham's son Isaac, his descendants are Jews & Edomites. From Abraham's son Ishmael, his descendants are Arabs. From Abraham's sons whom he had with his second wife, Keturah, his descendants are…
There are plenty of descendants from the Handel line, but none from the composer himself are known - he never married and died without any recognized heirs. That isn't to say that there *couldn't* be any - my own father was told as a child that his family was descended from the composer. If Handel did indeed father a child/children out of wedlock, then it was kept very quiet, since there are no official records.